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oai:repisalud.isciii.es:20.500.12105/154792024-09-27T23:47:59Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Falcon, A author Cuevas, Maria Teresa author Rodriguez-Frandsen, A author Reyes, Noelia author Pozo Sanchez, Francisco author Moreno, Silvia author Ledesma, Juan author Martínez-Alarcón, J author Nieto, A author Casas Flecha, Inmaculada author 2015-08 Influenza epidemics affect all age groups, although children, the elderly and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are in apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32 bp deletion in the CCR5 gene) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-Δ32 and evaluated its correlation with patient mortality. CCR5-Δ32 patients (17.4%) showed a higher mortality rate than WT individuals (4.7%; P = 0.021), which indicates that CCR5-Δ32 patients are at higher risk than the normal population of a fatal outcome in influenza infection. J Gen Virol. 2015 Aug;96(8):2074-2078. 10.1099/vir.0.000165 1465-2099 The Journal of general virology 25918237 http://hdl.handle.net/20.500.12105/15479 CCR5 deficiency predisposes to fatal outcome in influenza virus infection