2026-06-14T03:43:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/154592025-06-23T17:35:22Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Monge, Susana
author
Olmedo, Carmen
author
Alejos, Belén
author
Lapeña, María Fé
author
Sierra, María José
author
Limia, Aurora
author
COVID-19 Registries Study Group2
author
Mazagatos, Clara
author
Larrauri, Amparo
2023-02-07T10:56:28Z
2023-02-07T10:56:28Z
2021-10
Emerg Infect Dis. 2021 Oct;27(10):2595-2603.
10.3201/eid2710.211184
1080-6059
Emerging infectious diseases
34314670
http://hdl.handle.net/20.500.12105/15459
We conducted a registries-based cohort study of long-term care facility residents >65 years of age offered vaccination against severe acute respiratory syndrome coronavirus 2 before March 10, 2021, in Spain. Risk for infection in vaccinated and nonvaccinated persons was compared with risk in the same persons in a period before the vaccination campaign, adjusted by daily-varying incidence and reproduction number. We selected 299,209 persons; 99.0% had >1 dose, 92.6% had 2 doses, and 99.8% of vaccines were Pfizer/BioNTech (BNT162b2). For vaccinated persons with no previous infection, vaccine effectiveness was 81.8% (95% CI 81.0%-82.7%), and 11.6 (95% CI 11.3-11.9) cases were prevented per 10,000 vaccinated/day. In those with previous infection, effectiveness was 56.8% (95% CI 47.1%-67.7%). In nonvaccinated residents with no previous infection, risk decreased by up to 81.4% (95% CI 73.3%-90.3%). Our results confirm vaccine effectiveness in this population and suggest indirect protection in nonvaccinated persons.
eng
COVID-19
SARS-CoV-2
Spain
Coronavirus disease
Elderly
Indirect effects
Long-term care facilities
Respiratory infections
Severe acute respiratory syndrome coronavirus 2
Transmissibility
Vaccination
Vaccine effectiveness
Viruses
Zoonoses
Direct and Indirect Effectiveness of mRNA Vaccination against Severe Acute Respiratory Syndrome Coronavirus 2 in Long-Term Care Facilities, Spain
research article
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DirectIndirectEffectiveness_mRNAVaccination_2021 .pdf
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DirectIndirectEffectiveness_mRNAVaccination_2021 .pdf.txt