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oai:repisalud.isciii.es:20.500.12105/154582025-05-07T11:00:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Nielsen, J author Vestergaard, L S author Richter, L author Schmid, D author Bustos, N author Asikainen, T author Trebbien, R author Denissov, G author Innos, K author Virtanen, M J author Fouillet, A author Lytras, T author Gkolfinopoulou, K author Heiden, M An der author Grabenhenrich, L author Uphoff, H author Paldy, A author Bobvos, J author Domegan, Lisa author O'Donnell, J author Scortichini, M author de Martino, A author Mossong, J author England, K author Melillo, J author van Asten, L author de Lange, M Ma author Tønnessen, R author White, R A author da Silva, Susana P author Rodrigues, Ana Paula author Larrauri, Amparo author Mazagatos, Clara author Farah, A author Carnahan, A D author Junker, C author Sinnathamby, M author Pebody, Richard author Andrews, N author Reynolds, A author McMenamin, J author Brown, C S author Adlhoch, C author Penttinen, P author Mølbak, K author Krause, T G author 2019-10 Objectives: Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high excess mortality during the influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe all-cause excess and influenza-attributable mortality during the season 2017/18 in Europe. Methods: Based on weekly reporting of mortality from 24 European countries or sub-national regions, representing 60% of the European population excluding the Russian and Turkish parts of Europe, we estimated age stratified all-cause excess morality using the EuroMOMO model. In addition, age stratified all-cause influenza-attributable mortality was estimated using the FluMOMO algorithm, incorporating influenza activity based on clinical and virological surveillance data, and adjusting for extreme temperatures. Results: Excess mortality was mainly attributable to influenza activity from December 2017 to April 2018, but also due to exceptionally low temperatures in February-March 2018. The pattern and extent of mortality excess was similar to the previous A(H3N2) dominated seasons, 2014/15 and 2016/17. The 2017/18 overall all-cause influenza-attributable mortality was estimated to be 25.4 (95%CI 25.0-25.8) per 100,000 population; 118.2 (116.4-119.9) for persons aged 65. Extending to the European population this translates into over-all 152,000 deaths. Conclusions: The high mortality among elderly was unexpected in an influenza B dominated season, which commonly are considered to cause mild illness, mainly among children. Even though A(H3N2) also circulated in the 2017/18 season and may have contributed to the excess mortality among the elderly, the common perception of influenza B only having a modest impact on excess mortality in the older population may need to be reconsidered. Clin Microbiol Infect. 2019 Oct;25(10):1266-1276. 10.1016/j.cmi.2019.02.011 1469-0691 Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 30790685 http://hdl.handle.net/20.500.12105/15458 B/Yamagata EuroMOMO FluMOMO Influenza Mortality European all-cause excess and influenza-attributable mortality in the 2017/18 season: should the burden of influenza B be reconsidered?