2026-08-10T01:28:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/154312025-04-30T12:41:58Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988
Repisalud
author
Torres, Montserrat
author
Corona, Magdalena
author
Rodríguez-Mora, Sara
author
Casado-Fernández, Guiomar
author
Zurdo-Castronuño, Alejandro
author
Mateos, Elena
author
Ramos-Martín, Fernando
author
Sánchez-Menéndez, Clara
author
Murciano-Antón, María Aranzazu
author
García-Pérez, Javier
author
Alcamí, José
author
Perez-Olmeda, Mayte
author
Coiras, Mayte
author
López-Jiménez, Javier
author
García-Gutiérrez, Valentín
author
The Multidisciplinary Group Of Study Of Covid-Mgs-Covid
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Chiesi Foundation
funder
National Institutes of Health (Estados Unidos)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto Ramón y Cajal de Investigación Sanitaria (España)
2023-01-24T10:46:48Z
2023-01-24T10:46:48Z
2022-11-10
Cancers (Basel). 2022 Nov 10;14(22):5537.
10.3390/cancers14225537
2072-6694
Cancers
36428631
http://hdl.handle.net/20.500.12105/15431
The humoral immune response developed after receiving the full vaccination schedule against COVID-19 is impaired in individuals who received anti-CD20 therapy 6-9 months before vaccination. However, there is little information about the cellular immune responses elicited in these individuals. In this study, we analyzed the humoral and cellular immune responses in 18 individuals with hematological disease who received the last dose of rituximab 13.8 months (IQR 9.4-19) before the booster dose. One month after receiving the booster dose, the seroconversion rate in the rituximab-treated cohort increased from 83.3% to 88.9% and titers of specific IgGs against SARS-CoV-2 increased 1.53-fold (p = 0.0098), while the levels of neutralizing antibodies increased 3.03-fold (p = 0.0381). However, the cytotoxic activity of peripheral blood mononuclear cells (PBMCs) from rituximab-treated individuals remained unchanged, and both antibody-dependent cellular cytotoxicity (ADCC) and direct cellular cytotoxicity (CDD) were reduced 1.7-fold (p = 0.0047) and 2.0-fold (p = 0.0086), respectively, in comparison with healthy donors. Breakthrough infections rate was higher in our cohort of rituximab-treated individuals (33.33%), although most of the infected patients (83.4%) developed a mild form of COVID-19. In conclusion, our findings confirm a benefit in the humoral, but not in the cellular, immune response in rituximab-treated individuals after receiving a booster dose of an mRNA-based vaccine against COVID-19.
eng
COVID-19 vaccine
Anti-CD20
Rituximab
Hematological malignancies
Cytotoxic response
Humoral response
Strong Humoral but Not Cellular Immune Responses against SARS-CoV-2 in Individuals with Oncohematological Disease Who Were Treated with Rituximab before Receiving a Vaccine Booster
research article
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StrongHumoralNotCellularImmune_2022.pdf
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StrongHumoralNotCellularImmune_2022.pdf.txt