2026-08-10T01:37:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/154312025-04-30T12:41:58Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988

00925njm 22002777a 4500 dc Torres, Montserrat author Corona, Magdalena author Rodríguez-Mora, Sara author Casado-Fernández, Guiomar author Zurdo-Castronuño, Alejandro author Mateos, Elena author Ramos-Martín, Fernando author Sánchez-Menéndez, Clara author Murciano-Antón, María Aranzazu author García-Pérez, Javier author Alcamí, José author Perez-Olmeda, Mayte author Coiras, Mayte author López-Jiménez, Javier author García-Gutiérrez, Valentín author The Multidisciplinary Group Of Study Of Covid-Mgs-Covid author 2022-11-10 The humoral immune response developed after receiving the full vaccination schedule against COVID-19 is impaired in individuals who received anti-CD20 therapy 6-9 months before vaccination. However, there is little information about the cellular immune responses elicited in these individuals. In this study, we analyzed the humoral and cellular immune responses in 18 individuals with hematological disease who received the last dose of rituximab 13.8 months (IQR 9.4-19) before the booster dose. One month after receiving the booster dose, the seroconversion rate in the rituximab-treated cohort increased from 83.3% to 88.9% and titers of specific IgGs against SARS-CoV-2 increased 1.53-fold (p = 0.0098), while the levels of neutralizing antibodies increased 3.03-fold (p = 0.0381). However, the cytotoxic activity of peripheral blood mononuclear cells (PBMCs) from rituximab-treated individuals remained unchanged, and both antibody-dependent cellular cytotoxicity (ADCC) and direct cellular cytotoxicity (CDD) were reduced 1.7-fold (p = 0.0047) and 2.0-fold (p = 0.0086), respectively, in comparison with healthy donors. Breakthrough infections rate was higher in our cohort of rituximab-treated individuals (33.33%), although most of the infected patients (83.4%) developed a mild form of COVID-19. In conclusion, our findings confirm a benefit in the humoral, but not in the cellular, immune response in rituximab-treated individuals after receiving a booster dose of an mRNA-based vaccine against COVID-19. Cancers (Basel). 2022 Nov 10;14(22):5537. 10.3390/cancers14225537 2072-6694 Cancers 36428631 http://hdl.handle.net/20.500.12105/15431 COVID-19 vaccine Anti-CD20 Rituximab Hematological malignancies Cytotoxic response Humoral response Strong Humoral but Not Cellular Immune Responses against SARS-CoV-2 in Individuals with Oncohematological Disease Who Were Treated with Rituximab before Receiving a Vaccine Booster