2026-05-25T06:59:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/154292024-09-27T08:36:03Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sendra, Miquel
author
Domínguez, Jorge N
author
Torres, Miguel
author
Ocaña, Oscar H
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Comisión Europea
funder
Fundación La Caixa
funder
Fundación ProCNIC
2023-01-19T12:38:24Z
2023-01-19T12:38:24Z
2021-12-26
J Cardiovasc Dev Dis. 2021 Dec 26; 9(1):5
10.3390/jcdd9010005
2308-3425
Journal of cardiovascular development and disease
35050215
http://hdl.handle.net/20.500.12105/15429
Early heart development depends on the coordinated participation of heterogeneous cell sources. As pioneer work from Adriana C. Gittenberger-de Groot demonstrated, characterizing these distinct cell sources helps us to understand congenital heart defects. Despite decades of research on the segregation of lineages that form the primitive heart tube, we are far from understanding its full complexity. Currently, single-cell approaches are providing an unprecedented level of detail on cellular heterogeneity, offering new opportunities to decipher its functional role. In this review, we will focus on three key aspects of early heart morphogenesis: First, the segregation of myocardial and endocardial lineages, which yields an early lineage diversification in cardiac development; second, the signaling cues driving differentiation in these progenitor cells; and third, the transcriptional heterogeneity of cardiomyocyte progenitors of the primitive heart tube. Finally, we discuss how single-cell transcriptomics and epigenomics, together with live imaging and functional analyses, will likely transform the way we delve into the complexity of cardiac development and its links with congenital defects.
eng
Dissecting the Complexity of Early Heart Progenitor Cells.
journal article
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Dissecting the Complexity of Early J Cardiovasc Dev Dis 2021.pdf
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Dissecting the Complexity of Early J Cardiovasc Dev Dis 2021.pdf.txt