2026-04-27T07:54:48Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/154092024-11-29T10:27:28Zcom_20.500.12105_19604com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19605col_20.500.12105_16978
Repisalud
author
Villalba-Orero, María
author
Jiménez-Riobóo, Rafael J
author
Gontán, Nuria
author
Sanderson, Daniel
author
López-Olañeta, Marina
author
García-Pavía, Pablo
author
Desco, Manuel
author
Lara-Pezzi, Enrique
author
Gómez-Gaviro, Maria Victoria
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-01-09T13:55:02Z
2023-01-09T13:55:02Z
2021-11-01
Sci Rep. 2021 Nov 1;11(1):21369
http://hdl.handle.net/20.500.12105/15409
34725389
10.1038/s41598-021-00661-4
2045-2322
Scientific reports
Heart diseases are associated with changes in the biomechanical properties of the myocardial wall. However, there is no modality available to assess myocardial stiffness directly. Brillouin microspectroscopy (mBS) is a consolidated mechanical characterization technique, applied to the study of the viscoelastic and elastic behavior of biological samples and may be a valuable tool for assessing the viscoelastic properties of the cardiac tissue. In this work, viscosity and elasticity were assessed using mBS in heart samples obtained from healthy and unhealthy mice (n = 6 per group). Speckle-tracking echocardiography (STE) was performed to evaluate heart deformation. We found that mBS was able to detect changes in stiffness in the ventricles in healthy myocardium. The right ventricle showed reduced stiffness, in agreement with its increased compliance. mBS measurements correlated strongly with STE data, highlighting the association between displacement and stiffness in myocardial regions. This correlation was lost in pathological conditions studied. The scar region in the infarcted heart presented changes in stiffness when compared to the rest of the heart, and the hypertrophied left ventricle showed increased stiffness following aortic stenosis, compared to the right ventricle. We demonstrate that mBS can be applied to determine myocardial stiffness, that measurements correlate with functional parameters and that they change with disease.
eng
Assessment of myocardial viscoelasticity with Brillouin spectroscopy in myocardial infarction and aortic stenosis models.
journal article
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Assessment of myocardial viscoelasticity Sci Rep 2021.pdf
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Assessment of myocardial viscoelasticity Sci Rep 2021.pdf.txt