2026-06-14T05:05:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/154012024-09-27T09:09:17Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Del Pozo, Miguel A
author
Lolo, Fidel-Nicolás
author
Echarri, Asier
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Fundación La Marató TV3
funder
Worldwide Cancer Research Foundation
funder
Unión Europea. Comisión Europea. H2020
funder
Marie Curie
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-12-23T10:02:47Z
2022-12-23T10:02:47Z
2021-02
Curr Opin Cell Biol. 2021 Feb; 68:113-123
10.1016/j.ceb.2020.10.008
1879-0410
Current opinion in cell biology
33188985
http://hdl.handle.net/20.500.12105/15401
Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM-invaginated nanodomains with specific lipid and protein composition. Being highly abundant in mechanically challenged tissues (muscles, lungs, vessels, and adipose tissues), they protect cells from mechanical stress damage. Caveolae flatten upon increased PM tension, enabling both force sensing and accommodation, critical for cell mechanoprotection and homeostasis. Thus, caveolae are highly plastic, ranging in complexity from flattened membranes to vacuolar invaginations surrounded by caveolae-rosettes-which also contribute to mechanoprotection. Caveolar components crosstalk with mechanotransduction pathways and recent studies show that they translocate from the PM to the nucleus to convey stress information. Furthermore, caveolae components can regulate membrane traffic from/to the PM to adapt to environmental mechanical forces. The interdependence between lipids and caveolae starts to be understood, and the relevance of caveolae-dependent membrane trafficking linked to mechanoadaption to different physiopathological processes is emerging.
eng
Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation.
journal article
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Caveolae mechanosensing and mechanotransduction Curr Opin Cell Biol 2021.pdf
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Caveolae mechanosensing and mechanotransduction Curr Opin Cell Biol 2021.pdf.txt