2026-08-29T09:10:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/153802024-09-27T08:50:16Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Grivas, Dimitrios
author
González-Rajal, Álvaro
author
de la Pompa, José Luis
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Fundación BBVA
funder
Fundación La Marató TV3
funder
CardioNeT
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-12-22T12:01:18Z
2022-12-22T12:01:18Z
2021
Cell Dev Biol. 2021 May 7;9:669439
10.3389/fcell.2021.669439
2296-634X
Frontiers in cell and developmental biology
34026760
http://hdl.handle.net/20.500.12105/15380
Unlike the hearts of mammals, the adult zebrafish heart regenerates after injury. Heart cryoinjury in zebrafish triggers the formation of a fibrotic scar that gradually degrades, leading to regeneration. Midkine-a (Mdka) is a multifunctional cytokine that is activated after cardiac injury. Here, we investigated the role of mdka in zebrafish heart regeneration. We show that mdka expression was induced at 1-day post-cryoinjury (dpci) throughout the epicardial layer, whereas by 7 dpci expression had become restricted to the epicardial cells covering the injured area. To study the role of mdka in heart regeneration, we generated mdka-knock out (KO) zebrafish strains. Analysis of injured hearts showed that loss of mdka decreased endothelial cell proliferation and resulted in an arrest in heart regeneration characterized by retention of a collagenous scar. Transcriptional analysis revealed increases in collagen transcription and intense TGFβ signaling activity. These results reveal a critical role for mdka in fibrosis regulation during heart regeneration.
eng
Midkine-a Regulates the Formation of a Fibrotic Scar During Zebrafish Heart Regeneration.
journal article
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URL
https://repisalud.isciii.es/bitstreams/f74fc349-90d8-4158-8cf3-b715a4c0ca07/download
File
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application/pdf
Midkine_a Regulates the Formation Cell Dev Biol 2021.pdf
URL
https://repisalud.isciii.es/bitstreams/0115afc0-a205-445d-8649-49f7cbb77bef/download
File
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Midkine_a Regulates the Formation Cell Dev Biol 2021.pdf.txt