2026-08-29T14:55:55Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/152912025-05-07T13:06:11Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Sainz, Talia author Casas Flecha, Inmaculada author González-Esguevillas, Mónica author Escosa-Garcia, Luis author Muñoz-Fernández, María Ángeles author Prieto, Luis author Gosalbes, María José author Jiménez-Hernández, Nuria author Ramos, José Tomás author Navarro, María Luisa author Mellado, María José author Serrano-Villar, Sergio author Calvo, Cristina author 2022-07-19 Aims: Vaccine response is poor among children living with HIV. The gut microbiota has been identified as a potential target to improve vaccine immunogenicity, but data are scarce in the context of HIV infection. Methods: Pilot, double-blind, randomized placebo-controlled trial in which 24 HIV-infected children were randomized to receive a mixture of symbiotics, omega-3/6 fatty acids, and amino acids or placebo for 4 weeks, each in combination with ART, and were then immunized against influenza. Vaccine response and safety of the nutritional supplementation were the primary outcomes. Results: Eighteen HIV-infected children completed the follow-up period (mean age 11.5 ± 4.14 years, 61% female). The nutritional supplement was safe but did not enhance the response to the influenza vaccine. A 4-fold rise in antibody titers was obtained in only 37.5% of participants in the intervention arm vs. 40% in the placebo. No immunological or inflammatory predictors of vaccine response were identified. Conclusions: In this exploratory study, a 4-week course of symbiotics did not increase influenza vaccine immunogenicity in HIV-infected children. Larger studies are warranted to address the potential of modulating the microbiome in children living with HIV. Front Pediatr. 2022 Jul 19;10:919753. 10.3389/fped.2022.919753 2296-2360 Frontiers In Pediatrics 35928688 http://hdl.handle.net/20.500.12105/15291 HIV Children Immunoactivation Influenza vaccine response Microbiota Nutritional Supplementation to Increase Influenza Vaccine Response in Children Living With HIV: A Pilot Clinical Trial