2026-05-11T10:08:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/152562024-09-27T09:55:15Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Martos-Folgado, Inmaculada
author
Del Monte-Monge, Alberto
author
Lorenzo, Cristina
author
Busse, Christian E
author
Delgado, Pilar
author
Mur, Sonia M
author
Cobos-Figueroa, Laura
author
Escolà-Gil, Joan C
author
Martín-Ventura, Jose L
author
Wardemann, Hedda
author
Ramiro, Almudena R
funder
Ministerio de Economía y Competitividad (España)
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Fundación ProCNIC
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Centro de Investigación Biomédica en Red - CIBERDEM (Diabetes y Enfermedades Metabólicas asociadas)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-12-02T11:51:18Z
2022-12-02T11:51:18Z
2022-10-11
Cell Rep. 2022 Oct 11;41(2):111468
10.1016/j.celrep.2022.111468
2211-1247
Cell reports
36223741
http://hdl.handle.net/20.500.12105/15256
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1fl/flAicda-Cre+/kiLdlr-/- pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis.
eng
MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses.
journal article
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MDA_LDL vaccination induces Cell Rep 2022 Oct.pdf
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https://repisalud.isciii.es/bitstreams/5bc7ea1b-9413-4267-895e-dd9f2ac1dc41/download
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MDA_LDL vaccination induces Cell Rep 2022 Oct.pdf.txt