2026-05-11T10:08:17Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/152562024-09-27T09:55:15Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Martos-Folgado, Inmaculada author Del Monte-Monge, Alberto author Lorenzo, Cristina author Busse, Christian E author Delgado, Pilar author Mur, Sonia M author Cobos-Figueroa, Laura author Escolà-Gil, Joan C author Martín-Ventura, Jose L author Wardemann, Hedda author Ramiro, Almudena R author 2022-10-11 Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction, and stroke and is the leading cause of mortality worldwide. Immunization of pro-atherogenic mice with malondialdehyde-modified low-density lipoprotein (MDA-LDL) neo-antigen is athero-protective. However, the immune response to MDA-LDL and the mechanisms responsible for this athero-protection are not completely understood. Here, we find that immunization of mice with MDA-LDL elicits memory B cells, plasma cells, and switched anti-MDA-LDL antibodies as well as clonal expansion and affinity maturation, indicating that MDA-LDL triggers a bona fide germinal center antibody response. Further, Prdm1fl/flAicda-Cre+/kiLdlr-/- pro-atherogenic chimeras, which lack germinal center-derived plasma cells, show accelerated atherosclerosis. Finally, we show that MDA-LDL immunization is not athero-protective in mice lacking germinal-center-derived plasma cells. Our findings give further support to the development of MDA-LDL-based vaccines for the prevention or treatment of atherosclerosis. Cell Rep. 2022 Oct 11;41(2):111468 10.1016/j.celrep.2022.111468 2211-1247 Cell reports 36223741 http://hdl.handle.net/20.500.12105/15256 MDA-LDL vaccination induces athero-protective germinal-center-derived antibody responses.