2026-05-31T17:50:32Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/152542024-09-27T09:49:13Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Díaz-Díaz, Covadonga
author
Fernandez de Manuel, Laura
author
Jimenez-Carretero, Daniel
author
Montoya, María Concepción
author
Clavería, Cristina
author
Torres, Miguel
funder
Ministerio de Economía, Industria y Competitividad (España)
funder
Comunidad de Madrid (España)
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-12-01T15:42:25Z
2022-12-01T15:42:25Z
2017-09-25
Dev Cell 2017 Sep 25;42(6):585-599.e4
10.1016/j.devcel.2017.08.011
1878-1551
Developmental cell
28919206
http://hdl.handle.net/20.500.12105/15254
The mammalian epiblast is formed by pluripotent cells able to differentiate into all tissues of the new individual. In their progression to differentiation, epiblast cells and their in vitro counterparts, embryonic stem cells (ESCs), transit from naive pluripotency through a differentiation-primed pluripotent state. During these events, epiblast cells and ESCs are prone to death, driven by competition between Myc-high cells (winners) and Myc-low cells (losers). Using live tracking of Myc levels, we show that Myc-high ESCs approach the naive pluripotency state, whereas Myc-low ESCs are closer to the differentiation-primed state. In ESC colonies, naive cells eliminate differentiating cells by cell competition, which is determined by a limitation in the time losers are able to survive persistent contact with winners. In the mouse embryo, cell competition promotes pluripotency maintenance by elimination of primed lineages before gastrulation. The mechanism described here is relevant to mammalian embryo development and induced pluripotency.
eng
Pluripotency Surveillance by Myc-Driven Competitive Elimination of Differentiating Cells.
journal article
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URL
https://repisalud.isciii.es/bitstreams/bc9decae-ef08-4dd9-9334-06b752a8613a/download
File
MD5
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application/pdf
Pluripotency Surveillance by Myc_Dev Cell 2017 Sep.pdf
URL
https://repisalud.isciii.es/bitstreams/d8bcb962-4b68-4f5a-b36c-b1cb03f4b361/download
File
MD5
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text/plain
Pluripotency Surveillance by Myc_Dev Cell 2017 Sep.pdf.txt