2026-06-03T04:06:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/152532024-09-27T08:04:25Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lioux, Ghislaine
author
Liu, Xiaolei
author
Temiño, Susana
author
Oxendine, Michael
author
Ayala, Estefanía
author
Ortega, Sagrario
author
Kelly, Robert G
author
Oliver, Guillermo
author
Torres, Miguel
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Comunidad de Madrid (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-12-01T15:29:13Z
2022-12-01T15:29:13Z
2020-02-10
Dev Cell. 2020 Feb 10;52(3):350-363.e6
10.1016/j.devcel.2019.12.006
1878-1551
Developmental cell
31928974
http://hdl.handle.net/20.500.12105/15253
The mammalian heart contains multiple cell types that appear progressively during embryonic development. Advance in determining cardiac lineage diversification has often been limited by the unreliability of genetic tracers. Here we combine clonal analysis, genetic lineage tracing, tissue transplantation, and mutant characterization to investigate the lineage relationships between epicardium, arterial mesothelial cells (AMCs), and the coronary vasculature. We report a contribution of the second heart field (SHF) to a vasculogenic niche composed of AMCs and sub-mesothelial cells at the base of the pulmonary artery. Sub-mesothelial cells from this niche differentiate into lymphatic endothelial cells and, in close association with AMC-derived cells, contribute to and are essential for the development of ventral cardiac lymphatics. In addition, regionalized epicardial/mesothelial retinoic acid signaling regulates lymphangiogenesis, contributing to the niche properties. These results uncover a SHF vasculogenic contribution to coronary lymphatic development through a local niche at the base of the great arteries.
eng
A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics.
journal article
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URL
https://repisalud.isciii.es/bitstreams/d62f12b4-48fc-482d-9f2b-8a42fed4bd57/download
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A Second Heart Field Derived Dev Cell 2020 Feb 10.pdf
URL
https://repisalud.isciii.es/bitstreams/4e9a6e19-f8f7-4022-a6e7-d6ab75dc818d/download
File
MD5
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text/plain
A Second Heart Field Derived Dev Cell 2020 Feb 10.pdf.txt