2026-05-25T00:03:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/152502024-09-27T08:54:07Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Esteban, Isaac
author
Schmidt, Patrick
author
Desgrange, Audrey
author
Raiola, Morena
author
Temiño, Susana
author
Meilhac, Sigolène M.
author
Kobbelt, Leif
author
Torres, Miguel
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. H2020
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
funder
German Research Foundation
funder
Institut Pasteur
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-12-01T14:51:42Z
2022-12-01T14:51:42Z
2022-05-16
Esteban, I., Schmidt, P., Desgrange, A. et al. Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left–right asymmetry. Nat Cardiovasc Res 1, 504–517 (2022)
doi.org/10.1038/s44161-022-00065-1
2731-0590
Nature Cardiovascular Research
http://hdl.handle.net/20.500.12105/15250
Understanding organ morphogenesis requires a precise geometrical description of the tissues involved in the process. The
high morphological variability in mammalian embryos hinders the quantitative analysis of organogenesis. In particular, the
study of early heart development in mammals remains a challenging problem due to imaging limitations and complexity. Here,
we provide a complete morphological description of mammalian heart tube formation based on detailed imaging of a temporally dense collection of mouse embryonic hearts. We develop strategies for morphometric staging and quantification of local
morphological variations between specimens. We identify hot spots of regionalized variability and identify Nodal-controlled
left–right asymmetry of the inflow tracts as the earliest signs of organ left–right asymmetry in the mammalian embryo. Finally,
we generate a three-dimensional+t digital model that allows co-representation of data from different sources and provides a
framework for the computer modeling of heart tube formation
eng
Pseudodynamic analysis of heart tube formation in the mouse reveals strong regional variability and early left–right asymmetry
journal article
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Nat Cardiovasc Res 1 Pseudodynamic analysis of heart tube.pdf
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Nat Cardiovasc Res 1 Pseudodynamic analysis of heart tube.pdf.txt