2026-04-29T23:03:49Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/152392025-05-07T13:09:59Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610

00925njm 22002777a 4500 dc Tarazona, Jose author Cattaneo, Irene author Niemann, Lars author Pedraza-Diaz, Susana author González-Caballero, MCarmen author De Alba-González, Mercedes author Cañas Portilla, Ana Isabel author Domínguez-Morueco, Noelia author Esteban-Lopez, Marta author Castaño, Argelia author Borges, Teresa author Katsonouri, Andromachi author Makris, Konstantinos C author Ottenbros, Ilse author Mol, Hans author De Decker, Annelies author Morrens, Bert author Berman, Tamar author Barnett-Itzhaki, Zohar author Probst-Hensch, Nicole author Fuhrimann, Samuel author Tratnik, Janja Snoj author Horvat, Milena author Rambaud, Loïc author Riou, Margaux author Schoeters, Greet author Govarts, Eva author Kolossa-Gehring, Marike author Weber, Till author Apel, Petra author Namorado, Sónia author Santonen, Tiina author 2022-08-04 Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th percentiles from HBM4EU aligned studies (2014-2021) covering children in Belgium, Cyprus, France, Israel, Slovenia, and The Netherlands and adults in France, Germany, Israel, and Switzerland. In all children populations, the 95th percentiles for 3-phenoxybenzoic acid (3-PBA) exceeded the screening value. The probabilistic refinement quantified the risk level of the most exposed population (Belgium) at 2% or between 1-0.1% depending on the assumptions. In the substance specific assessments, the 95th percentiles of urinary concentrations in the aligned studies were well below the respective human biomonitoring guidance values (HBM-GVs). Both information sets were combined for refining the combined risk. Overall, the HBM data suggest a low health concern, at population level, related to pyrethroid exposure for the populations covered by the studies, even though a potential risk for highly exposed children cannot be completely excluded. The proposed tiered approach, including a screening step and several refinement options, seems to be a promising tool of scientific and regulatory value in future. Toxics. 2022 Aug 4;10(8):451. 10.3390/toxics10080451 2305-6304 Toxics 36006130 http://hdl.handle.net/20.500.12105/15239 HBM4EU Biocides Combined pyrethroid risk assessment Guidance values Human biomonitoring Pesticides Pyrethroids Screening assessment Tiered approach Veterinary drugs A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data