2026-05-06T02:12:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/152262025-03-26T08:23:26Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sánchez-Castillo, Carla
author
Cuartero, María I
author
Fernández-Rodrigo, Alba
author
Briz, Víctor
author
López-García, Sergio
author
Jiménez-Sánchez, Raquel
author
López, Juan A
author
Graupera, Mariona
author
Esteban, José A
author
Briz, Víctor
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía (España)
funder
Marie Curie
funder
Intertalentum Postdoctoral Program
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Agencia Estatal de Investigación (España)
2022-11-24T08:45:14Z
2022-11-24T08:45:14Z
2022-11-25
Sci Adv. 2022 Nov 25;8(47):eabq8109.
10.1126/sciadv.abq8109
2375-2548
Science advances
36417513
http://hdl.handle.net/20.500.12105/15226
Neuronal connectivity and activity-dependent synaptic plasticity are fundamental properties that support brain function and cognitive performance. Phosphatidylinositol 3-kinase (PI3K) intracellular signaling controls multiple mechanisms mediating neuronal growth, synaptic structure, and plasticity. However, it is still unclear how these pleiotropic functions are integrated at molecular and cellular levels. To address this issue, we used neuron-specific virally delivered Cre expression to delete either p110α or p110β (the two major catalytic isoforms of type I PI3K) from the hippocampus of adult mice. We found that dendritic and postsynaptic structures are almost exclusively supported by p110α activity, whereas p110β controls neurotransmitter release and metabotropic glutamate receptor-dependent long-term depression at the presynaptic terminal. In addition to these separate functions, p110α and p110β jointly contribute to N-methyl-d-aspartate receptor-dependent postsynaptic long-term potentiation. This molecular and functional specialization is reflected in different proteomes controlled by each isoform and in distinct behavioral alterations for learning/memory and sociability in mice lacking p110α or p110β.
eng
Functional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition.
research article
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Sci Adv 2022 Nov 25_8 Functional specialization of different PI3K.pdf
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https://repisalud.isciii.es/bitstreams/36a78e31-b3d9-4dd2-889a-b3ed38255ab4/download
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Sci Adv 2022 Nov 25_8 Functional specialization of different PI3K.pdf.txt