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oai:repisalud.isciii.es:20.500.12105/152172024-09-27T17:59:52Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Romaní Vidal, Adriana author Vaughan, Aisling author Innocenti, Francesco author Colombe, Soledad author Nerlander, Lina author Rachwal, Natalia author Ciancio, Bruno Christian author Mougkou, Aikaterini author Carvalho, Carlos author Delgado, Enrique author Mook, Piers author de Muylder, Géraldine author Peeters, Michael author Tenev, Tencho author Golkocheva-Markova, Elitsa author Vorobieva Solholm Jensen, Veronika author Koch, Anders author Figoni, Julie author Brouard, Cécile author Nikolopoulou, Georgia author Zisouli, Anastasia author Murphy, Niamh author Broderick, Annemarie author Goldberg, Lital author Rich, Rivka author Hecht Sagie, Lior author Tosti, Maria Elena author Suligoi, Barbara author Joosten, Rosa author Pijnacker, Roan author Fjeldheim, Ingvild author Heen, Eli author Stępień, Małgorzata author Polański, Piotr author Tato Marinho, Rui author Vieira Martins, João author Varela Martinez, Maria del Carmen author Avellón, Ana author Andersson, Emmi author Jansson Mörk, Marie author Mandal, Sema author Watson, Conall author Coughlan, Laura author Chand, Meera author Neill, Claire author Bradley, Declan T author Li, Kathy author O'Leary, Maureen author McInnes, Neil author Williams, Christopher J author Moore, Catherine author Gjini, Ardiana author Duffell, Erika author Pebody, Richard author 2022-08 Following the report of an excess in paediatric cases of severe acute hepatitis of unknown aetiology by the United Kingdom (UK) on 5 April 2022, 427 cases were reported from 20 countries in the World Health Organization European Region to the European Surveillance System TESSy from 1 January 2022 to 16 June 2022. Here, we analysed demographic, epidemiological, clinical and microbiological data available in TESSy. Of the reported cases, 77.3% were 5 years or younger and 53.5% had a positive test for adenovirus, 10.4% had a positive RT-PCR for SARS-CoV-2 and 10.3% were coinfected with both pathogens. Cases with adenovirus infections were significantly more likely to be admitted to intensive care or high-dependency units (OR = 2.11; 95% CI: 1.18-3.74) and transplanted (OR = 3.36; 95% CI: 1.19-9.55) than cases with a negative test result for adenovirus, but this was no longer observed when looking at this association separately between the UK and other countries. Aetiological studies are needed to ascertain if adenovirus plays a role in this possible emergence of hepatitis cases in children and, if confirmed, the mechanisms that could be involved. Euro Surveill. 2022 Aug;27(31):2200483. 10.2807/1560-7917.ES.2022.27.31.2200483 1560-7917 Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 35929429 http://hdl.handle.net/20.500.12105/15217 TESSy WHO European Region Adenovirus Hepatitis Paediatric acute liver failure Europe Unknown aetiology Hepatitis of unknown aetiology in children - epidemiological overview of cases reported in Europe, 1 January to 16 June 2022