2026-04-29T22:57:33Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/152072024-09-27T09:08:53Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hoffmann, Jedrzej
author
Richardson, Gavin
author
Haendeler, Judith
author
Altschmied, Joachim
author
Andres, Vicente
author
Spyridopoulos, Ioakim
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Progeria Research Foundation
funder
British Heart Foundation
funder
National Institute for Health Research (Reino Unido)
funder
Newcastle Biomedical Research Centre
funder
Tyne Hospitals NHS Foundation Trust
funder
Deutsche Forschungsgemeinschaft (Alemania)
funder
Telomerase Activator to Reverse Immunosenescence in Acute Coronary Syndrome
2022-11-21T11:38:09Z
2022-11-21T11:38:09Z
2021
Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1047-1061.
10.1161/ATVBAHA.120.315695
1524-4636
Arteriosclerosis, thrombosis, and vascular biology
33504179
http://hdl.handle.net/20.500.12105/15207
Shortened telomeres have been linked to numerous chronic diseases, most importantly coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function mutations and deletions in telomerase both accelerate telomere shortening but do not necessarily lead to a clinical phenotype associated with atherosclerosis, questioning the causal role of telomere length in cardiac pathology. The differential extranuclear functions of the 2 main components of telomerase, telomerase reverse transcriptase and telomerase RNA component, offer important clues about the complex relationship between telomere length and cardiovascular pathology. In this review, we critically discuss relevant preclinical models, genetic disorders, and clinical studies to elucidate the impact of telomerase in cardiovascular disease and its potential role as a therapeutic target. We suggest that the antioxidative function of mitochondrial telomerase reverse transcriptase might be atheroprotective, making it a potential target for clinical trials. Graphic Abstract: A graphic abstract is available for this article.
eng
Telomerase as a Therapeutic Target in Cardiovascular Disease.
journal article
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URL
https://repisalud.isciii.es/bitstreams/ab4cb090-3760-4cbf-a844-65cff6138a2f/download
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Arterioscler Thromb Vasc Biol 2021 41_3_Telomerase as a Therapeutic Target.pdf
URL
https://repisalud.isciii.es/bitstreams/a3262e58-fc48-41a4-9c98-3fb25ba7b986/download
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Arterioscler Thromb Vasc Biol 2021 41_3_Telomerase as a Therapeutic Target.pdf.txt