2026-08-29T08:19:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151932024-11-29T12:26:13Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988col_20.500.12105_16990
Repisalud
author
Muñoz-Chimeno, Milagros
author
Bartúren, Silvia
author
Garcia-Lugo, Maira Alejandra
author
Morago, Lucia
author
Rodriguez-Recio, Alvaro
author
Galán, Juan Carlos
author
Pérez-Rivilla, Alfredo
author
Rodríguez, Mercedes
author
Millán, Rosario
author
Del Álamo, Manuel
author
Alonso, Roberto
author
Molina, Laura
author
Aguinaga, Aitziber
author
Avellón, Ana
funder
Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública)
2022-11-18T13:43:10Z
2022-11-18T13:43:10Z
2022-06
Euro Surveill. 2022 Jun;27(23):2100542.
10.2807/1560-7917.ES.2022.27.23.2100542
1560-7917
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
35686567
http://hdl.handle.net/20.500.12105/15193
Background: Hepatitis E virus genotype 3 (HEV-3) is widely distributed throughout Europe, with incidence of infections increasing in many countries. Belgium, Bulgaria, France, Germany, Italy, the Netherlands and the United Kingdom have reported the distribution of HEV-3 subtypes in cohorts of patients with hepatic disease. Aim: To describe the distribution of the HEV-3 subtypes in Spain at national and autonomous community (AC) levels between 2009 and 2019. The study was also extended to Andorra. Methods: Of 5,197 samples received by the National Reference Laboratory during the study, 409 were HEV-RNA-positive. Among these, 294 (71.9%) were further typed based on an ORF2 sequence fragment, or, for a subset of 74, based on the full-coding genome sequence. Results: HEV-3 was detected in 291 samples. The dominant subtype in Spain was HEV-3f (88.3%; 257/291), which occurred in all ACs, with no change in detection level over time. Within this subtype, three subclusters were characterised: HEV-3f-B, HEV-3f-A1 and HEV-3f-A2. The second most common HEV subtype was the recently described HEV-3m (7%; 21/291), with two subclusters identified: HEV-3m-A, which has been known since 2010, and HEV-3m-B, since 2014. The third most encountered subtype was HEV-3c (4.1%; 12/291), with a frequency not increasing over time, unlike observations in some European countries. Conclusion: The importance of the surveillance of HEV-3 subtype and subcluster circulation is yet to be assessed. This surveillance together with the comprehensive epidemiological characterisation of clinical cases, could support the identification of sources of transmission and the establishment of control measures nationally and internationally.
eng
HEV
Hepatitis E
Spain
Genotype 3
Subtype
Hepatitis E virus genotype 3 microbiological surveillance by the Spanish Reference Laboratory: geographic distribution and phylogenetic analysis of subtypes from 2009 to 2019
journal article
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https://repisalud.isciii.es/bitstreams/24cce5ab-c01d-4138-8ed0-a7d2326d9a4d/download
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application/pdf
HepatitisEVirusGenotype3Microbiological_2022.pdf
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https://repisalud.isciii.es/bitstreams/9893e0e7-bbd2-493b-aeef-c3febeb925a3/download
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text/plain
HepatitisEVirusGenotype3Microbiological_2022.pdf.txt