2026-06-14T02:29:16Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/151862025-05-05T17:43:29Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Ceballos, Francisco C author Virseda-Berdices, Ana author Resino, Salvador author Ryan, Pablo author Martínez-González, Oscar author Perez-Garcia, Felipe author Martin-Vicente, Maria author Brochado-Kith, Oscar author Blancas, Rafael author Bartolomé-Sánchez, Sofía author Vidal-Alcántara, Erick Joan author Albóniga-Díez, Oihane Elena author Cuadros-González, Juan author Blanca-López, Natalia author Martinez, Isidoro author Ramirez Martinez-Acitores, Ignacio author Barbas, Coral author Fernandez-Rodriguez, Amanda author Jimenez-Sousa, Maria Angeles author 2022-06-30 Background: metabolic changes through SARS-CoV-2 infection has been reported but not fully comprehended. This metabolic dysregulation affects multiple organs during COVID-19 and its early detection can be used as a prognosis marker of severity. Therefore, we aimed to characterize metabolic and cytokine profile at COVID-19 onset and its relationship with disease severity to identify metabolic profiles predicting disease progression. Material and methods: we performed a retrospective cross-sectional study in 123 COVID-19 patients which were stratified as asymptomatic/mild, moderate and severe according to the highest COVID-19 severity status, and a group of healthy controls. We performed an untargeted plasma metabolic profiling (gas chromatography and capillary electrophoresis-mass spectrometry (GC and CE-MS)) and cytokine evaluation. Results: After data filtering and identification we observed 105 metabolites dysregulated (66 GC-MS and 40 CE-MS) which shown different expression patterns for each COVID-19 severity status. These metabolites belonged to different metabolic pathways including amino acid, energy, and nitrogen metabolism among others. Severity-specific metabolic dysregulation was observed, as an increased transformation of L-tryptophan into L-kynurenine. Thus, metabolic profiling at hospital admission differentiate between severe and moderate patients in the later phase of worse evolution. Several plasma pro-inflammatory biomarkers showed significant correlation with deregulated metabolites, specially with L-kynurenine and L-tryptophan. Finally, we describe a strong sex-related dysregulation of metabolites, cytokines and chemokines between severe and moderate patients. In conclusion, metabolic profiling of COVID-19 patients at disease onset is a powerful tool to unravel the SARS-CoV-2 molecular pathogenesis. Conclusions: This technique makes it possible to identify metabolic phenoconversion that predicts disease progression and explains the pronounced pathogenesis differences between sexes. Front Immunol. 2022 Jun 30;13:925558. 10.3389/fimmu.2022.925558 1664-3224 Frontiers in immunology 35844615 http://hdl.handle.net/20.500.12105/15186 COVID-19 Metabolomics Severity Sex-specific Spanish hospitals Disease onset Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation