2026-06-14T03:40:12Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/151832025-06-25T12:33:53Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19614

00925njm 22002777a 4500 dc Marquez-Megias, Silvia author Nalda-Molina, Ricardo author Sanz-Valero, Javier author Más-Serrano, Patricio author Diaz-Gonzalez, Marcos author Candela-Boix, Maria Remedios author Ramon-Lopez, Amelia author 2022-05-07 Infliximab and adalimumab are monoclonal antibodies against tumor necrosis factor (anti-TNF) used to manage inflammatory bowel disease (IBD). Therapeutic Drug Monitoring (TDM) has been proven to prevent immunogenicity, to achieve better long-term clinical results and to save costs in IBD treatment. The aim of this study was to conduct a systematic review on cost-effectiveness analyses of studies that apply TDM of anti-TNF in IBD and to provide a critical analysis of the best scientific knowledge available in the literature. The quality of the included studies was assessed using Consolidated Health Economic Evaluation Reporting Standards (CHEERS). Cost-effectiveness of the TDM strategies was presented as total costs, cost savings, quality-adjusted life-years (QALY) and incremental cost-effectiveness ratio (ICER). Thirteen studies that examined the health economics of TDM of anti-TNF in IBD from 2013 to 2021 were included. Eight of them (61.5%) achieved a score between 17 and 23 on the CHEERS checklist. The comparison between the TDM strategy and an empirical strategy was cost saving. The ICER between reactive TDM and an empirical strategy was dominated (favorable) by reactive TDM, whereas the ICER value for proactive TDM compared to an empirical strategy ranged from EUR 56,845 to 3,901,554. This systematic review demonstrated that a TDM strategy is cost-effective or cost-saving in IBD. Pharmaceutics. 2022 May 7;14(5):1009. 10.3390/pharmaceutics14051009 1999-4923 Pharmaceutics 35631594 http://hdl.handle.net/20.500.12105/15183 Inflammatory bowel diseases Drug monitoring Pharmacokinetics Tumor necrosis factor inhibitors Adalimumab Infliximab Cost–benefit analysis Cost-effectiveness Cost-Effectiveness of Therapeutic Drug Monitoring of Anti-TNF Therapy in Inflammatory Bowel Disease: A Systematic Review