2026-06-14T02:28:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151802025-06-13T07:54:09Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616col_20.500.12105_19617
Repisalud
author
Bernabeu-Zornoza, Adela
author
Coronel Lopez, Raquel
author
Palmer, Charlotte
author
Martin, Alberto
author
López-Alonso, Victoria
author
Liste-Noya, Isabel
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Comunidad de Madrid (España)
2022-11-17T14:04:13Z
2022-11-17T14:04:13Z
2022-05-22
Int J Mol Sci. 2022 May 22;23(10):5820.
10.3390/ijms23105820
1422-0067
International journal of molecular sciences
35628629
http://hdl.handle.net/20.500.12105/15180
Amyloid-β 40 peptides [Aβ1-40 (Aβ40)] are present within amyloid plaques in the brains of patients with Alzheimer's disease (AD). Even though Aβ peptides are considered neurotoxic, they can mediate many biological processes, both in adult brains and throughout brain development. However, the physiological function of these Aβ peptides remains poorly understood, and the existing data are sometimes controversial. Here, we analyze and compare the effects of monomeric Aβ40 on the biology of differentiating human neural stem cells (human NSCs). For that purpose, we used a model of human NSCs called hNS1. Our data demonstrated that Aβ40 at high concentrations provokes apoptotic cellular death and the damage of DNA in human NSCs while also increasing the proliferation and favors neurogenesis by raising the percentage of proliferating neuronal precursors. These effects can be mediated, at least in part, by β-catenin. These results provide evidence of how Aβ modulate/regulate human NSC proliferation and differentiation, suggesting Aβ40 may be a pro-neurogenic factor. Our data could contribute to a better understanding of the molecular mechanisms involved in AD pathology and to the development of human NSC-based therapies for AD treatment, since these results could then be used in diagnosing the disease at early stages and be applied to the development of new treatment options.
eng
Aβ40
Human neural stem cells
Alzheimer’s
Neurogenesis
Cell proliferation
Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide
research article
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URL
https://repisalud.isciii.es/bitstreams/392c44f4-87df-4a8d-85c3-5a85551c9992/download
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NeurogenesisIsIncreasedHumanNeural_2022.pdf
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https://repisalud.isciii.es/bitstreams/017d0a53-64ee-48b2-b5b9-63818866b69c/download
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NeurogenesisIncreasedHumanNeural_2022.pdf.txt
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https://repisalud.isciii.es/bitstreams/a28331ac-ddc0-4669-a3b6-74d736a7075d/download
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NeurogenesisIsIncreasedHumanNeural_2022.pdf.txt