2026-04-29T12:25:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151792025-06-13T10:26:00Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617
Repisalud
author
Magro-Lopez, Esmeralda
author
Chamorro-Herrero, Irene
author
Zambrano, Alberto
funder
Instituto de Salud Carlos III
2022-11-17T13:50:10Z
2022-11-17T13:50:10Z
2022-04-28
Int J Mol Sci. 2022 Apr 28;23(9):4921.
10.3390/ijms23094921
1422-0067
International journal of molecular sciences
35563311
http://hdl.handle.net/20.500.12105/15179
In our previous work, we evaluated the therapeutic effects of 1α,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in the context of bleomycin-induced lung fibrosis. Contrary to the expected, vitamin D supplementation increased the DNA damage expression and cellular senescence in alveolar epithelial type II cells and aggravated the overall lung pathology induced in mice by bleomycin. These effects were probably due to an alteration in the cellular DNA double-strand breaks' repair capability. In the present work, we have evaluated the effects of two hypocalcemic vitamin D analogs (calcipotriol and paricalcitol) in the expression of DNA damage in the context of minilungs derived from human embryonic stem cells and in the cell line A549.
eng
Human pluripotent stem cells
hESCs
Minilungs
Vitamin D
Vitamin D analogs
Paricalcitol
Calcipotriol
Lung fibrosis
Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis
research article
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EffectsHypocalcemicVitaminDAnalogs_2022.pdf
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EffectsHypocalcemicVitaminDAnalogs_2022.pdf.txt