2026-04-29T12:25:15Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/151792025-06-13T10:26:00Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19617

00925njm 22002777a 4500 dc Magro-Lopez, Esmeralda author Chamorro-Herrero, Irene author Zambrano, Alberto author 2022-04-28 In our previous work, we evaluated the therapeutic effects of 1α,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in the context of bleomycin-induced lung fibrosis. Contrary to the expected, vitamin D supplementation increased the DNA damage expression and cellular senescence in alveolar epithelial type II cells and aggravated the overall lung pathology induced in mice by bleomycin. These effects were probably due to an alteration in the cellular DNA double-strand breaks' repair capability. In the present work, we have evaluated the effects of two hypocalcemic vitamin D analogs (calcipotriol and paricalcitol) in the expression of DNA damage in the context of minilungs derived from human embryonic stem cells and in the cell line A549. Int J Mol Sci. 2022 Apr 28;23(9):4921. 10.3390/ijms23094921 1422-0067 International journal of molecular sciences 35563311 http://hdl.handle.net/20.500.12105/15179 Human pluripotent stem cells hESCs Minilungs Vitamin D Vitamin D analogs Paricalcitol Calcipotriol Lung fibrosis Effects of Hypocalcemic Vitamin D Analogs in the Expression of DNA Damage Induced in Minilungs from hESCs: Implications for Lung Fibrosis