2026-06-14T03:46:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151702024-09-27T09:42:19Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Huerta-López, Carla
author
Alegre-Cebollada, Jorge
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2022-11-16T14:22:21Z
2022-11-16T14:22:21Z
2021-06-24
Nanomaterials (Basel) . 2021 Jun 24;11(7):1656
10.3390/nano11071656
2079-4991
Nanomaterials (Basel, Switzerland)
34202469
http://hdl.handle.net/20.500.12105/15170
Biomaterials are dynamic tools with many applications: from the primitive use of bone and wood in the replacement of lost limbs and body parts, to the refined involvement of smart and responsive biomaterials in modern medicine and biomedical sciences. Hydrogels constitute a subtype of biomaterials built from water-swollen polymer networks. Their large water content and soft mechanical properties are highly similar to most biological tissues, making them ideal for tissue engineering and biomedical applications. The mechanical properties of hydrogels and their modulation have attracted a lot of attention from the field of mechanobiology. Protein-based hydrogels are becoming increasingly attractive due to their endless design options and array of functionalities, as well as their responsiveness to stimuli. Furthermore, just like the extracellular matrix, they are inherently viscoelastic in part due to mechanical unfolding/refolding transitions of folded protein domains. This review summarizes different natural and engineered protein hydrogels focusing on different strategies followed to modulate their mechanical properties. Applications of mechanically tunable protein-based hydrogels in drug delivery, tissue engineering and mechanobiology are discussed.
eng
Protein Hydrogels: The Swiss Army Knife for Enhanced Mechanical and Bioactive Properties of Biomaterials.
journal article
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URL
https://repisalud.isciii.es/bitstreams/45f36c85-92dd-446b-a8be-ecbf4517803b/download
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Nanomaterials Basel 2021 Jun Protein Hydrogels The Swiss Army.pdf
URL
https://repisalud.isciii.es/bitstreams/31bb8cf6-3559-4adb-8eba-60948d02834a/download
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Nanomaterials Basel 2021 Jun Protein Hydrogels The Swiss Army.pdf.txt