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oai:repisalud.isciii.es:20.500.12105/151642024-09-27T09:54:26Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud author Abdellatif, Mahmoud author Trummer-Herbst, Viktoria author Koser, Franziska author Durand, Sylvère author Adão, Rui author Vasques-Nóvoa, Francisco author Freundt, Johanna K author Voglhuber, Julia author Pricolo, Maria-Rosaria author Kasa, Michael author Türk, Clara author Aprahamian, Fanny author Herrero-Galán, Elías author Hofer, Sebastian J author Pendl, Tobias author Rech, Lavinia author Kargl, Julia author Anto-Michel, Nathaly author Ljubojevic-Holzer, Senka author Schipke, Julia author Brandenberger, Christina author Auer, Martina author Schreiber, Renate author Koyani, Chintan N author Heinemann, Akos author Zirlik, Andreas author Schmidt, Albrecht author von Lewinski, Dirk author Scherr, Daniel author Rainer, Peter P author von Maltzahn, Julia author Mühlfeld, Christian author Krüger, Marcus author Frank, Saša author Madeo, Frank author Eisenberg, Tobias author Prokesch, Andreas author Leite-Moreira, Adelino F author Lourenço, André P author Alegre-Cebollada, Jorge author Kiechl, Stefan author Linke, Wolfgang A author Kroemer, Guido author Sedej, Simon funder European Research Area Network on Cardiovascular Diseases funder MINOTAUR consortium funder FWF Austrian Science Fund funder Agence Nationale de la Recherche (Francia) funder Bundesministerium für Bildung und Forschung funder Instituto de Salud Carlos III funder Fundação para a Ciência e Tecnologia (Portugal) funder European Society of Cardiology funder Austrian Society of Cardiology funder Ligue Nationale Contre le Cancer (Francia) funder Fondation ARC pour la recherche sur le cancer funder Association Ruban Rose funder Chancelerie des universités de Paris funder Fondation pour la recherche médicale (Francia) funder Institut National du Cancer funder Institut Universitaire de France funder Fondation Leducq funder LabEx Immuno-Oncology funder Ministerio de Ciencia e Innovación (España) funder Comunidad de Madrid (España) funder Austrian Research Promotion Agency funder Pustertaler Verein zur Prävention von Herz-und Hirngefäßerkrankungen funder Gesundheitsbezirk Bruneck funder Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 2022-11-16T11:09:17Z 2022-11-16T11:09:17Z 2021 Sci Transl Med . 2021 Feb 10;13(580):eabd7064 10.1126/scitranslmed.abd7064 1946-6242 Science translational medicine 33568522 http://hdl.handle.net/20.500.12105/15164 Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we show that diastolic dysfunction in patients with HFpEF is associated with a cardiac deficit in nicotinamide adenine dinucleotide (NAD+). Elevating NAD+ by oral supplementation of its precursor, nicotinamide, improved diastolic dysfunction induced by aging (in 2-year-old C57BL/6J mice), hypertension (in Dahl salt-sensitive rats), or cardiometabolic syndrome (in ZSF1 obese rats). This effect was mediated partly through alleviated systemic comorbidities and enhanced myocardial bioenergetics. Simultaneously, nicotinamide directly improved cardiomyocyte passive stiffness and calcium-dependent active relaxation through increased deacetylation of titin and the sarcoplasmic reticulum calcium adenosine triphosphatase 2a, respectively. In a long-term human cohort study, high dietary intake of naturally occurring NAD+ precursors was associated with lower blood pressure and reduced risk of cardiac mortality. Collectively, these results suggest NAD+ precursors, and especially nicotinamide, as potential therapeutic agents to treat diastolic dysfunction and HFpEF in humans. eng Nicotinamide for the treatment of heart failure with preserved ejection fraction. journal article 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 URL https://repisalud.isciii.es/bitstreams/afac2538-d9fb-4f0a-b857-7e8c7231ff29/download File MD5 8d4edb89e5e338568663402ffce94645 3825301 application/pdf Sci Transl Med 2021 Feb 10 Nicotinamide for the treatment.pdf URL https://repisalud.isciii.es/bitstreams/93ad5232-b5a4-4d1d-ba95-2e1345f10978/download File MD5 c9897b8f997b7a743ae0a12847ca25c4 80336 text/plain Sci Transl Med 2021 Feb 10 Nicotinamide for the treatment.pdf.txt