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oai:repisalud.isciii.es:20.500.12105/151562024-09-27T08:15:07Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Roszer, Tamás author Menéndez-Gutiérrez, María P author Lefterova, Martina I author Alameda, Daniel author Núñez, Vanessa author Lazar, Mitchell A author Fischer, Thierry author Ricote, Mercedes author 2011-01-01 Autoimmune glomerulonephritis is a common manifestation of systemic lupus erythematosus (SLE). In this study, we show that mice lacking macrophage expression of the heterodimeric nuclear receptors PPARγ or RXRα develop glomerulonephritis and autoantibodies to nuclear Ags, resembling the nephritis seen in SLE. These mice show deficiencies in phagocytosis and clearance of apoptotic cells, and they are unable to acquire an anti-inflammatory phenotype upon feeding of apoptotic cells, which is critical for the maintenance of self-tolerance. These results demonstrate that stimulation of PPARγ and RXRα in macrophages facilitates apoptotic cell engulfment, and they provide a potential strategy to avoid autoimmunity against dying cells and to attenuate SLE. J Immunol . 2011 Jan 1;186(1):621-31. 10.4049/jimmunol.1002230 1550-6606 Journal of immunology (Baltimore, Md. : 1950) 21135166 http://hdl.handle.net/20.500.12105/15156 Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency.