2026-08-05T11:42:01Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151392024-09-27T07:58:17Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Moore-Morris, Thomas
author
Cattaneo, Paola
author
Guimarães-Camboa, Nuno
author
Bogomolovas, Julius
author
Cedenilla, Marta
author
Banerjee, Indroneal
author
Ricote, Mercedes
author
Kisseleva, Tatiana
author
Zhang, Lunfeng
author
Gu, Yusu
author
Dalton, Nancy D
author
Peterson, Kirk L
author
Chen, Ju
author
Pucéat, Michel
author
Evans, Sylvia M
funder
American Heart Association
funder
Marie Curie
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
Ministerio de Educación, Cultura y Deporte (España)
funder
Fondation Leducq
2022-11-15T10:45:10Z
2022-11-15T10:45:10Z
2018
Circ Res . 2018 Feb 16;122(4):583-590. doi: 10.1161/CIRCRESAHA.117.311490. Epub 2017 Dec 21.
10.1161/CIRCRESAHA.117.311490
1524-4571
Circulation research
29269349
http://hdl.handle.net/20.500.12105/15139
Myocardial infarction is a major cause of adult mortality worldwide. The origin(s) of cardiac fibroblasts that constitute the postinfarct scar remain controversial, in particular the potential contribution of bone marrow lineages to activated fibroblasts within the scar.
The aim of this study was to establish the origin(s) of infarct fibroblasts using lineage tracing and bone marrow transplants and a robust marker for cardiac fibroblasts, the Collagen1a1-green fluorescent protein reporter.
Using genetic lineage tracing or bone marrow transplant, we found no evidence for collagen-producing fibroblasts derived from hematopoietic or bone marrow lineages in hearts subjected to permanent left anterior descending coronary artery ligation. In fact, fibroblasts within the infarcted area were largely of epicardial origin. Intriguingly, collagen-producing fibrocytes from hematopoietic lineages were observed attached to the epicardial surface of infarcted and sham-operated hearts in which a suture was placed around the left anterior descending coronary artery.
In this controversial field, our study demonstrated that the vast majority of infarct fibroblasts were of epicardial origin and not derived from bone marrow lineages, endothelial-to-mesenchymal transition, or blood. We also noted the presence of collagen-producing fibrocytes on the epicardial surface that resulted at least in part from the surgical procedure.
eng
Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages.
journal article
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Circ Res 2018 Infarct Fibroblasts Do Not Derive_RICOTE.pdf
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Circ Res 2018 Infarct Fibroblasts Do Not Derive_RICOTE.pdf.txt