2026-06-14T02:28:57Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151382025-06-06T13:19:53Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Sepulveda-Crespo, Daniel
author
Yélamos, María Belén
author
Díez, Cristina
author
Gómez, Julián
author
Hontañón, Víctor
author
Torresano-Felipe, Francisco
author
Berenguer, Juan
author
González-García, Juan
author
Ibañez-Samaniego, Luis
author
Llop, Elva
author
Olveira, Antonio
author
Martínez, Javier
author
Resino, Salvador
author
Martinez, Isidoro
funder
Instituto de Salud Carlos III
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
2022-11-15T10:31:47Z
2022-11-15T10:31:47Z
2022-06
Biomed Pharmacother. 2022 Jun;150:113024.
10.1016/j.biopha.2022.113024
1950-6007
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
35483197
http://hdl.handle.net/20.500.12105/15138
Objectives: The current study aimed to assess the impact of HIV on the production of anti-HCV antibodies in HCV-infected individuals with advanced HCV-related cirrhosis before and 36 weeks after the sustained virological response (SVR) induced by direct-acting antivirals (DAAs) therapy. Methods: Prospective study on 62 patients (50 HIV/HCV-coinfected and 12 HCV-monoinfected). Plasma anti-E2 and HCV-nAbs were determined respectively by ELISA and microneutralization assays. Results: At baseline, the HCV-group had higher anti-E2 levels against Gt1a (p = 0.012), Gt1b (p = 0.023), and Gt4a (p = 0.005) than the HIV/HCV-group. After SVR, anti-E2 titers against Gt1a (p < 0.001), Gt1b (p = 0.001), and Gt4a (p = 0.042) were also higher in the HCV-group than HIV/HCV-group. At 36 weeks post-SVR, plasma anti-E2 titers decreased between 1.3 and 1.9-fold in the HIV/HCV-group (p < 0.001) and between 1.5 and 1.8-fold in the HCV-group (p ≤ 0.001). At baseline, the HCV-group had higher titers of HCV-nAbs against Gt1a (p = 0.022), Gt1b (p = 0.002), Gt2a (p < 0.001), and Gt4a (p < 0.001) than the HIV/HCV-group. After SVR, HCV-nAbs titers against Gt1a (p = 0.014), Gt1b (p < 0.001), Gt2a (p = 0.002), and Gt4a (p = 0.004) were also higher in the HCV-group. At 36 weeks post-SVR, HCV-nAbs decreased between 2.6 and 4.1-fold in the HIV/HCV-group (p < 0.001) and between 1.9 and 4.0-fold in the HCV-group (p ≤ 0.001). Conclusions: HIV/HCV-coinfected patients produced lower levels of broad-spectrum anti-HCV antibodies than HCV-monoinfected patients.
eng
Hepatitis C
HIV
HIV/HCV coinfection
Broad-spectrum neutralizing antibodies
Direct-acting antivirals
HCV clearance
Negative impact of HIV infection on broad-spectrum anti-HCV neutralizing antibody titers in HCV-infected patients with advanced HCV-related cirrhosis
research article
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NegativeImpactHIVInfection_2022.pdf
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cb18acf01859106e5d3d69c58e7e1201
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NegativeImpactHIVInfection_2022.pdf.txt