2026-06-14T00:43:19Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151292024-11-28T17:16:47Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_19604col_20.500.12105_16959col_20.500.12105_16967col_20.500.12105_16971col_20.500.12105_16973col_20.500.12105_16976col_20.500.12105_16978col_20.500.12105_16984col_20.500.12105_16972col_20.500.12105_16990col_20.500.12105_19607
Repisalud
author
López, Mariana G
author
Chiner-Oms, Álvaro
author
García de Viedma, Darío
author
Ruiz-Rodriguez, Paula
author
Bracho, Maria Alma
author
Cancino-Muñoz, Irving
author
D'Auria, Giuseppe
author
de Marco, Griselda
author
García-González, Neris
author
Goig, Galo Adrian
author
Gómez-Navarro, Inmaculada
author
Jiménez-Serrano, Santiago
author
Martinez-Priego, Llúcia
author
Ruiz-Hueso, Paula
author
Ruiz-Roldán, Lidia
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Torres-Puente, Manuela
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Alberola, Juan
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Albert, Eliseo
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Aranzamendi Zaldumbide, Maitane
author
Bea-Escudero, María Pilar
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Boga, Jose Antonio
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Bordoy, Antoni E
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Canut-Blasco, Andrés
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Carvajal, Ana
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Cilla Eguiluz, Gustavo
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Cordón Rodríguez, Maria Luz
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Costa-Alcalde, José J
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de Toro, María
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de Toro Peinado, Inmaculada
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Del Pozo, Jose Luis
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Duchêne, Sebastián
author
Fernández-Pinero, Jovita
author
Fuster Escrivá, Begoña
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Gimeno Cardona, Concepción
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González Galán, Verónica
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Gonzalo Jiménez, Nieves
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Hernáez Crespo, Silvia
author
Herranz, Marta
author
Lepe, José Antonio
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López-Causapé, Carla
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López-Hontangas, José Luis
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Martín, Vicente
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Martró, Elisa
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Milagro Beamonte, Ana
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Montes Ros, Milagrosa
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Moreno-Muñoz, Rosario
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Navarro, David
author
Navarro-Marí, José María
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Not, Anna
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Oliver, Antonio
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Palop-Borrás, Begoña
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Parra Grande, Mónica
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Pedrosa-Corral, Irene
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Pérez González, Maria Carmen
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Pérez-Lago, Laura
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Pérez-Ruiz, Mercedes
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Piñeiro Vázquez, Luis
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Rabella, Nuria
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Rezusta, Antonio
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Robles Fonseca, Lorena
author
Rodríguez-Villodres, Ángel
author
Sanbonmatsu-Gámez, Sara
author
Sicilia, Jon
author
Soriano, Alex
author
Tirado Balaguer, María Dolores
author
Torres, Ignacio
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Tristancho, Alexander
author
Marimón, José María
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Coscolla, Mireia
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González-Candelas, Fernando
author
Comas, Iñaki
funder
Instituto de Salud Carlos III
funder
Consejo Superior de Investigaciones Científicas (España)
funder
Ministerio de Ciencia (España)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Generalitat Valenciana (España)
2022-11-14T13:38:52Z
2022-11-14T13:38:52Z
2021
Nat Genet . 2021 Oct;53(10):1405-1414. doi: 10.1038/s41588-021-00936-6. Epub 2021 Sep 30.
10.1038/s41588-021-00936-6
1546-1718
Nature genetics
34594042
http://hdl.handle.net/20.500.12105/15129
The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants.
eng
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant.
journal article
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Nature Genetics_The first wave of the COVID_19_2021.pdf
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https://repisalud.isciii.es/bitstreams/afe02a5d-da67-43c1-b618-0b8bcaf5e737/download
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Nature Genetics_The first wave of the COVID_19_2021.pdf.txt