2026-04-29T00:34:15Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/151282024-09-27T10:09:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607
Repisalud
author
Delgado-Arévalo, Cristina
author
Calvet-Mirabent, Marta
author
Triguero-Martinez, Ana
author
Vázquez de Luis, Enrique
author
Benguría-Filippini, Alberto
author
Largo, Raquel
author
Calzada-Fraile, Diego
author
Popova, Olga
author
Sánchez-Cerrillo, Ildefonso
author
Tsukalov, Ilya
author
Moreno-Vellisca, Roberto
author
de la Fuente, Hortensia
author
Herrero-Beaumont, Gabriel
author
Ramiro, Almudena R
author
Sánchez-Madrid, Francisco
author
Castañeda, Santos
author
Dopazo, Ana
author
González-Álvaro, Isidoro
author
Martin-Gayo, Enrique
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Fundación La Caixa
funder
Fundación La Marató TV3
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2022-11-14T13:10:36Z
2022-11-14T13:10:36Z
2022-10-04
JCI Insight . 2022 Oct 4;e152886. doi: 10.1172/jci.insight.152886.
http://hdl.handle.net/20.500.12105/15128
36194479
10.1172/jci.insight.152886
2379-3708
JCI insight
The individual contribution of specific myeloid subsets such as CD1c+ conventional dendritic cells (cDC) to perpetuation of Rheumatoid Arthritis (RA) pathology remains unclear. In addition, the specific innate sensors driving pathogenic activation of CD1c+ cDCs in RA patients and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional and functional characteristics of CD1c+ and CD141+ cDCs and monocytes from the blood and synovial fluid of RA patients. Increased levels of CCR2 and the IgG receptor CD64 on circulating CD1c+ cDC associated with the presence of this DC subset in the synovial membrane in RA patients. Moreover, synovial CD1c+ cDCs are characterized by increased expression of proinflammatory cytokines and high abilities to induce pathogenic IFNγ+IL-17+ CD4+ T cells in vitro. Finally, we identified the crosstalk between Fcγ Receptors and NLRC4 as a new potential molecular mechanism mediating pathogenic activation, CD64 upregulation and functional specialization of CD1c+ cDCs in response to dsDNA-IgG in RA patients.
eng
NLRC4 -mediated activation of CD1c+ dendritic cells contributes to perpetuation of synovitis in rheumatoid arthritis.
journal article
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URL
https://repisalud.isciii.es/bitstreams/f72b19b1-2cc5-47f1-b171-9a192c05c659/download
File
MD5
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application/pdf
JCI_2022_NLRC4 _mediated activation of CD1.pdf
URL
https://repisalud.isciii.es/bitstreams/4e550e08-1ed1-4b25-8495-db7b36b400ce/download
File
MD5
8df6f394c3a68f8e50d472af0f07fdf7
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text/plain
JCI_2022_NLRC4 _mediated activation of CD1.pdf.txt