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oai:repisalud.isciii.es:20.500.12105/151282024-09-27T10:09:29Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19607

00925njm 22002777a 4500 dc Delgado-Arévalo, Cristina author Calvet-Mirabent, Marta author Triguero-Martinez, Ana author Vázquez de Luis, Enrique author Benguría-Filippini, Alberto author Largo, Raquel author Calzada-Fraile, Diego author Popova, Olga author Sánchez-Cerrillo, Ildefonso author Tsukalov, Ilya author Moreno-Vellisca, Roberto author de la Fuente, Hortensia author Herrero-Beaumont, Gabriel author Ramiro, Almudena R author Sánchez-Madrid, Francisco author Castañeda, Santos author Dopazo, Ana author González-Álvaro, Isidoro author Martin-Gayo, Enrique author 2022-10-04 The individual contribution of specific myeloid subsets such as CD1c+ conventional dendritic cells (cDC) to perpetuation of Rheumatoid Arthritis (RA) pathology remains unclear. In addition, the specific innate sensors driving pathogenic activation of CD1c+ cDCs in RA patients and their functional implications have not been characterized. Here, we assessed phenotypical, transcriptional and functional characteristics of CD1c+ and CD141+ cDCs and monocytes from the blood and synovial fluid of RA patients. Increased levels of CCR2 and the IgG receptor CD64 on circulating CD1c+ cDC associated with the presence of this DC subset in the synovial membrane in RA patients. Moreover, synovial CD1c+ cDCs are characterized by increased expression of proinflammatory cytokines and high abilities to induce pathogenic IFNγ+IL-17+ CD4+ T cells in vitro. Finally, we identified the crosstalk between Fcγ Receptors and NLRC4 as a new potential molecular mechanism mediating pathogenic activation, CD64 upregulation and functional specialization of CD1c+ cDCs in response to dsDNA-IgG in RA patients. JCI Insight . 2022 Oct 4;e152886. doi: 10.1172/jci.insight.152886. http://hdl.handle.net/20.500.12105/15128 36194479 10.1172/jci.insight.152886 2379-3708 JCI insight NLRC4 -mediated activation of CD1c+ dendritic cells contributes to perpetuation of synovitis in rheumatoid arthritis.