2026-04-29T12:31:20Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/151072024-09-27T08:10:47Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Blanco-Domínguez, Rafael author de la Fuente, Hortensia author Rodríguez, Cristina author Martín-Aguado, Laura author Sánchez-Díaz, Raquel author Jiménez-Alejandre, Rosa author Rodriguez-Arabaolaza, Iker author Curtabbi, Andrea author Garcia-Guimaraes, Marcos M author Vera, Alberto author Rivero, Fernando author Cuesta, Javier author Jimenez-Borreguero, Luis Jesus author Cecconi, Alberto author Duran-Cambra, Albert author Taurón, Manel author Alonso, Judith author Bueno, Hector author Villalba-Orero, María author Enriquez, Jose Antonio author Robson, Simon C author Alfonso, Fernando author Sánchez-Madrid, Francisco author Martínez-González, José author Martin, Pilar author Garcia-Guimaraes, Marcos M. author Robson, Simon C. author 2022-09-06 Increasing evidences advocate for an important function of T cells in controlling immune homeostasis and pathogenesis after myocardial infarction (MI), although the underlying molecular mechanisms remain elusive. In this study, a broad analysis of immune markers in 283 patients revealed a significant CD69 overexpression on Treg cells after MI. Our results in mice showed that CD69 expression on Treg cells increased survival after left-anterior-descending coronary artery (LAD)-ligation. Cd69-/- mice developed strong IL-17+ γδT cell responses after ischemia that increased myocardial inflammation and, consequently, worsened cardiac function. CD69+ Treg cells, by induction of AhR-dependent CD39 ectonucleotidase activity, induced apoptosis and decreased IL-17A production in γδT cells. Adoptive transfer of CD69+ Treg cells to Cd69-/- mice after LAD-ligation reduced IL-17+ γδT cell recruitment, thus increasing survival. Consistently, clinical data from two independent cohorts of patients indicated that increased CD69 expression in peripheral blood cells after acute MI was associated with a lower risk of re-hospitalization for heart failure (HF) after 2.5 years of follow-up. This result remained significant after adjustment for age, sex and traditional cardiac damage biomarkers. Our data highlight CD69 expression on Treg cells as a potential prognostic factor and a therapeutic option to prevent HF after MI. J Clin Invest . 2022 Sep 6;e152418. 10.1172/JCI152418 1558-8238 The Journal of clinical investigation 36066993 http://hdl.handle.net/20.500.12105/15107 CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.