2026-04-22T17:33:24Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/150982025-04-01T10:22:00Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Hernández-García, Elena
author
Cueto, Francisco J
author
Cook, Emma CL
author
Redondo-Urzainqui, Ana
author
Charro-Zanca, Sara
author
Robles-Vera, Iñaki
author
Conde-Garrosa, Ruth
author
Nikolić, Ivana
author
Sabio, Guadalupe
author
Sancho, David
author
Iborra, Salvador
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Comunidad de Madrid (España)
funder
Fundación La Marató TV3
funder
Atresmedia
funder
Unión Europea. Comisión Europea. 7 Programa Marco
funder
EFSD/Lilly European Diabetes Research Programme GS
funder
Leonardo Grant for Researchers and Cultural Creators
funder
Asociación Española Contra el Cáncer
funder
Eli Lilly
funder
Instituto de Salud Carlos III
funder
Fundación ProCNIC
funder
Fundación BBVA
2022-10-26T11:02:07Z
2022-10-26T11:02:07Z
2022-02
Cellular & Molecular Immunology volume 19, pages260–275 (2022)
http://hdl.handle.net/20.500.12105/15098
34983945
10.1038/s41423-021-00812-7
2042-0226
Cellular & molecular immunology
Conventional dendritic cells (cDCs) scan and integrate environmental cues in almost every tissue, including exogenous metabolic signals. While cDCs are critical in maintaining immune balance, their role in preserving energy homeostasis is unclear. Here, we showed that Batf3-deficient mice lacking conventional type 1 DCs (cDC1s) had increased body weight and adiposity during aging. This led to impaired energy expenditure and glucose tolerance, insulin resistance, dyslipidemia, and liver steatosis. cDC1 deficiency caused adipose tissue inflammation that was preceded by a paucity of NK1.1+ invariant NKT (iNKT) cells. Accordingly, among antigen-presenting cells, cDC1s exhibited notable induction of IFN-γ production by iNKT cells, which plays a metabolically protective role in lean adipose tissue. Flt3L treatment, which expands the dendritic cell (DC) compartment, mitigated diet-induced obesity and hyperlipidemia in a Batf3-dependent manner. This effect was partially mediated by NK1.1+ cells. These results reveal a new critical role for the cDC1-iNKT cell axis in the regulation of adipose tissue homeostasis.
eng
Conventional type 1 dendritic cells protect against age-related adipose tissue dysfunction and obesity.
journal article
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application/pdf
Conventional type 1 dendritic cells_2022.pdf
URL
https://repisalud.isciii.es/bitstreams/5c97253e-ac04-4366-9b20-7bfec09bd744/download
File
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Conventional type 1 dendritic cells_2022.pdf.txt