2026-07-22T20:05:50Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/150802024-11-29T21:51:43Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
Valiente, Manuel
author
García-Gómez, Pedro
2022-10-21T09:12:20Z
2022-10-21T09:12:20Z
2020
Tumor Vascularization. eds.Domenico Ribatti, Francesco Pezzella.London, Elsevier, 2020. En:Vascular co-option/ Pedro García Gomez, Manuel Valiente.a Zhu, Manuel Valiente. 2020, pags.33-47.
https://doi.org/10.1016/C2019-0-00115-X
978-0-12-819494-2
http://hdl.handle.net/20.500.12105/15080
Vascular co-option is an alternative mechanism to interact with blood vessels used by normal cells and hijacked by cancer cells. Functional experiments using in vivo models have demonstrated that co-option of pre-existing capillary networks is a critical step for the initiation of multiorgan metastases from different cancer types. Thus targeting this process pharmacologically is a very promising strategy to prevent metastases. Vascular co-option supports the viability of disseminated tumor cells, even when they remain dormant. Additionally, targeting vascular co-option could be a valuable strategy to challenge the emergence of resistance to more conventional therapies.
eng
vascular co-option
capillaries
Metastasis
dormancy
immunosuppression
aggressiveness
adhesion
stemness
angiocrine factors
Vascular co-option
book part
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vascularcooption_2020.pdf
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vascularcooption_2020.pdf.txt