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00925njm 22002777a 4500 dc Palomar-Cros, Anna author Harding, Barbara N author Espinosa, Ana author Papantoniou, Kyriaki author Perez-Gomez, Beatriz author Straif, Kurt author Ardanaz, Eva author Fernández-Villa, Tania author Amiano, Pilar author Gómez-Acebo, Inés author Moreno, Victor author Alguacil, Juan author Fernández-Tardón, Guillermo author Molina-Barceló, Ana author Marcos-Gragera, Rafael author Aragones, Nuria author Castaño-Vinyals, Gemma author Guevara, Marcela author Marcos Delgado, Alba author Pollan-Santamaria, Marina author Romaguera, Dora author Kogevinas, Manolis author 2022-08-11 Circadian nutritional behaviors, defined by the daily eating/fasting cycle, have been linked with breast cancer. This study aimed to further disentangle the association of nighttime fasting duration and time of breakfast with breast cancer risk. We analyzed data from 1,181 breast cancer cases and 1,326 population controls from the Spanish multicase-control study (MCC-Spain), 2008-2013. We collected circadian nutritional behaviors at mid-age via a telephonic interview. We applied logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of nighttime fasting duration and time of breakfast with breast cancer risk in all women and stratified by menopausal status. Models were adjusted for age, center, education, family history of breast cancer, age at menarche, number of children, breastfeeding, age at first child, body mass index (BMI), contraceptive use, and hormonal replacement therapy (HRT). A later time of breakfast was associated with a non-significant increased risk of breast cancer (OR = 1.05, 95% CI: 0.95-1.16, per hour increase). This association was stronger among premenopausal women, among whom each hour later, the time of breakfast was associated with an 18% increase in breast cancer risk (OR = 1.18, 95% CI: 1.01-1.40). The association was not observed in postmenopausal women. We did not observe an association between nighttime fasting duration and breast cancer risk after adjusting for the time of breakfast. In this study, late breakfast was associated with increased breast cancer risk, especially among premenopausal women, compared with early breakfast. Aside from nutritional quality, circadian nutritional behaviors should be further studied in relation to cancer. Front Nutr. 2022 Aug 11;9:941477. 10.3389/fnut.2022.941477 2296-861X Frontiers in Nutrition http://hdl.handle.net/20.500.13003/18189 36034928 2-s2.0-85136597648 http://hdl.handle.net/20.500.12105/15066 844372400001 Breakfast Breast cancer risk Chrononutrition Circadian nutritional behaviors Circadian rhythms Meal timing Nighttime fasting duration Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain