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oai:repisalud.isciii.es:20.500.12105/150552024-11-29T17:33:24Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc Valiente, Manuel author Marín, Oscar author 2010-02 Neuronal migration is a fundamental process that determines the final allocation of neurons in the nervous system, establishing the basis for the subsequent wiring of neural circuitry. From cell polarization to target identification, neuronal migration integrates multiple cellular and molecular events that enable neuronal precursors to move across the brain to reach their final destination. In this review we summarize novel findings on the key processes that govern the cell biology of migrating neurons, describing recent advances in their molecular regulation in different migratory pathways of the brain, spinal cord, and peripheral nervous system. We will also review how this basic knowledge is contributing to a better understanding of the etiology and pathophysiology of multiple neurological syndromes in which neuronal migration is disrupted. Curr Opin Neurobiol. 2010 ;20(1):68-78. 10.1016/j.conb.2009.12.003 1873-6882 Current opinion in neurobiology 20053546 http://hdl.handle.net/20.500.12105/15055 Neuronal migration mechanisms in development and disease.