2026-04-29T00:59:58Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/150532024-11-30T00:43:26Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597
Repisalud
author
García-Gómez, Pedro
author
Priego, Neibla
author
Álvaro-Espinosa, Laura
author
Valiente, Manuel
funder
Ministerio de Ciencia e Innovación (España)
funder
Bristol-Myers Squibb
funder
Beug Foundation for Metastasis Research
funder
Fundación Ramón Areces
funder
Unión Europea. Comisión Europea. H2020
funder
Cancer Research Institute (CRI). Clinic & Laboratory Integration Program (CLIP)
funder
Asociación Española Contra el Cáncer
funder
European Molecular Biology Organization
2022-10-14T09:45:10Z
2022-10-14T09:45:10Z
2020
García-Gómez, P., Priego, N., Álvaro-Espinosa, L., Valiente, M. (2020). Brain Metastases Cell Partners and Tumor Microenvironment. In: Ahluwalia, M., Metellus, P., Soffietti, R. (eds) Central Nervous System Metastases. Springer, Cham.
978-3-030-23417-1
http://hdl.handle.net/20.500.12105/15053
10.1007/978-3-030-23417-1_5
The microenvironment has emerged as a promising source of novel therapeutic applications in experimental models of brain metastasis. Our limited understanding of the complex brain ecosystem transformed by the presence of cancer cells includes key cell types that either promote or limit local progression of metastatic cells. Identification of the molecular networks regulating the crosstalk between cancer cells and the microenvironment but also within different brain resident and non-resident cell types surrounding the tumor is crucial to decipher the biology of colonization and subsequently to target key nodes with innovative and effective therapies.
eng
Astrocytes
Microglia
Macrophages
Lymphocytes
Endothelial cells
Vascular co-option
Angiogenesis
Immunotherapy
Brain Metastases Cell Partners and Tumor Microenvironment
book part
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