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oai:repisalud.isciii.es:20.500.12105/150532024-11-30T00:43:26Zcom_20.500.12105_2173com_20.500.12105_2051col_20.500.12105_19597

00925njm 22002777a 4500 dc García-Gómez, Pedro author Priego, Neibla author Álvaro-Espinosa, Laura author Valiente, Manuel author 2020 The microenvironment has emerged as a promising source of novel therapeutic applications in experimental models of brain metastasis. Our limited understanding of the complex brain ecosystem transformed by the presence of cancer cells includes key cell types that either promote or limit local progression of metastatic cells. Identification of the molecular networks regulating the crosstalk between cancer cells and the microenvironment but also within different brain resident and non-resident cell types surrounding the tumor is crucial to decipher the biology of colonization and subsequently to target key nodes with innovative and effective therapies. García-Gómez, P., Priego, N., Álvaro-Espinosa, L., Valiente, M. (2020). Brain Metastases Cell Partners and Tumor Microenvironment. In: Ahluwalia, M., Metellus, P., Soffietti, R. (eds) Central Nervous System Metastases. Springer, Cham. 978-3-030-23417-1 http://hdl.handle.net/20.500.12105/15053 10.1007/978-3-030-23417-1_5 Astrocytes Microglia Macrophages Lymphocytes Endothelial cells Vascular co-option Angiogenesis Immunotherapy Brain Metastases Cell Partners and Tumor Microenvironment