2026-07-21T14:19:55Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/149572025-06-18T07:04:59Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16962col_20.500.12105_19616

00925njm 22002777a 4500 dc Ruano, David author López-Martín, José A author Moreno, Lucas author Lassaletta, Álvaro author Bautista, Francisco author Andión, Maitane author Hernández, Carmen author González-Murillo, África author Melen, Gustavo author Alemany, Ramón author Madero, Luis author Garcia-Castro, Javier author Ramírez, Manuel author 2020-04-08 We present here the results of a first-in-human, first-in-child trial for patients with relapsed/refractory solid tumors using Celyvir, an advanced therapy medicine that combines autologous mesenchymal stem cells (MSCs) carrying an oncolytic adenovirus. Celyvir was manufactured from a bone marrow aspirate and then given intravenously. Patients received weekly infusions for 6 weeks at a dose of 2 × 106 cells/kg (children) or 0.5-1 × 106 cells/kg (adults), 2 × 104 viral particles per cell. Fifteen pediatric and 19 adult patients were recruited, but 18 were screen failures, mainly because rapid disease progression before Celyvir was available. No grade 2-5 toxicities were reported. Adenoviral replication detected by PCR was found in all but 2 pediatric patient and in none of the adult ones. Absolute numbers of circulating leukocytes suffered minor changes along therapy, but some subsets showed differences comparing the pediatric versus the adult cohorts. Two patients with neuroblastoma showed disease stabilization, and one of them continued on treatment for up to 6 additional weeks. Celyvir, the combination of MSCs and oncolytic adenovirus, is safe and warrants further evaluation in a phase 2 setting. The use of MSCs may be a strategy to increase the amount of oncolytic virus administered to patients, minimizing toxicities and avoiding direct tumor injections. Mol Ther. 2020 Apr 8;28(4):1033-1042. 10.1016/j.ymthe.2020.01.019 1525-0024 Molecular therapy : the journal of the American Society of Gene Therapy 32053771 http://hdl.handle.net/20.500.12105/14957 Clinical trial Mesenchymal stem cells Oncolytic virotherapy Pediatric tumor First-in-Human, First-in-Child Trial of Autologous MSCs Carrying the Oncolytic Virus Icovir-5 in Patients with Advanced Tumors