2026-07-21T10:47:34Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/149432024-09-27T21:29:47Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
de la Torre-Tarazona, Humberto Erick
author
Ayala-Suarez, Ruben
author
Díez-Fuertes, Francisco
author
Alcamí, José
funder
Instituto de Salud Carlos III
funder
Gilead Sciences (Spain)
funder
Red de Investigación Cooperativa en Investigación en Sida (España)
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
2022-09-05T07:46:01Z
2022-09-05T07:46:01Z
2022-07-01
Front Immunol. 2022 Jul 1;13:926499.
10.3389/fimmu.2022.926499
1664-3224
Frontiers in immunology
35844607
http://hdl.handle.net/20.500.12105/14943
This article reviews the main discoveries achieved by transcriptomic approaches on HIV controller (HIC) and long-term non-progressor (LTNP) individuals, who are able to suppress HIV replication and maintain high CD4+ T cell levels, respectively, in the absence of antiretroviral therapy. Different studies using high throughput techniques have elucidated multifactorial causes implied in natural control of HIV infection. Genes related to IFN response, calcium metabolism, ribosome biogenesis, among others, are commonly differentially expressed in LTNP/HIC individuals. Additionally, pathways related with activation, survival, proliferation, apoptosis and inflammation, can be deregulated in these individuals. Likewise, recent transcriptomic studies include high-throughput sequencing in specific immune cell subpopulations, finding additional gene expression patterns associated to viral control and/or non-progression in immune cell subsets. Herein, we provide an overview of the main differentially expressed genes and biological routes commonly observed on immune cells involved in HIV infection from HIC and LTNP individuals, analyzing also different technical aspects that could affect the data analysis and the future perspectives and gaps to be addressed in this field.
eng
Transcriptome (RNA-seq)
HIV infection
Long-term non-progressor (LTNP)
HIV controllers (HIC)
Omics
Immune cells
Omic Technologies in HIV: Searching Transcriptional Signatures Involved in Long-Term Non-Progressor and HIV Controller Phenotypes
journal article
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URL
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File
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OmicTechnologiesHIV_Searching_2022.pdf
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https://repisalud.isciii.es/bitstreams/e58e79f9-2f76-44b1-a2e0-fbd327fdb4e5/download
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text/plain
OmicTechnologiesHIV_Searching_2022.pdf.txt