2026-05-17T05:46:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/149342025-05-14T10:15:33Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963
Repisalud
author
Sánchez García, Laura
author
Calvo, Cristina
author
Casas Flecha, Inmaculada
author
Pozo Sanchez, Francisco
author
Pellicer, Adelina
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
2022-09-02T09:56:46Z
2022-09-02T09:56:46Z
2020-09-22
BMJ Paediatr Open. 2020 Sep 22;4(1):e000661.
10.1136/bmjpo-2020-000661
2399-9772
BMJ Paediatrics Open
33024832
http://hdl.handle.net/20.500.12105/14934
Background and objective: Very low birthweight (VLBW) infants are highly susceptible to respiratory infections. Information about prevalence of viral respiratory infections (VRIs) in neonatal intensive care unit (NICU) is scarce. Recent evidence suggests short-term and long-term impact of VRI in morbidity of VLBW infants. The goal of this study is to conduct a VRI surveillance in VLBW infants during NICU admission to address the prevalence, type of viruses and associated clinical features. Methods: Prospective observational cohort study on infants below 32 gestational weeks admitted to a tertiary NICU during a 2-year period. Respiratory virus detection (influenza, parainfluenza, rhinovirus (hRV), enterovirus, respiratory syncytial virus, metapneumovirus, coronavirus, bocavirus and adenovirus) was performed by real time multiplex PCR assays in nasopharyngeal aspirates (NPAs), within the first 72 hours after birth and weekly, until discharge. Additional samples were taken if clinically indicated. Results: 147 out of 224 eligible infants were enrolled. At least one positive NPA was found in 38% of the study cohort. Main viruses identified were hRV (58%) and adenovirus (31%). Among the 56 infants with positive NPA, 26 showed non-specific respiratory features in 58% (increased respiratory workload, tachypnoea, apnoea) or typical cold features in 38% (rhinorrhea, cough, fever), at least in one episode. Antibiotics were prescribed in 29% of cases. Positive infants showed higher rates of bronchopulmonary dysplasia (BPD), need for supplemental oxygen and mechanical ventilation, and had longer hospital stay. Cox regression analysis found BPD as an independent risk factor for viral infection (p<0.001) and symptomatic VRI (p<0.04). Conclusions: Systematic surveillance in VLBW infants reports VRI is frequent, particularly by hRV. Asymptomatic infection is highly prevalent which is critical in the face of establishing appropriate preventive strategies. Infants with BPD are especially vulnerable to such infections.
eng
Infectious diseases
Neonatology
Respiratory
Virology
Viral respiratory infections in very low birthweight infants at neonatal intensive care unit: prospective observational study
research article
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URL
https://repisalud.isciii.es/bitstreams/c948e8b1-cc8d-4162-849a-00b9fc6b7def/download
File
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application/pdf
ViralRespiratoryInfectionsVeryLow_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/cf0e459c-2379-41c7-88dc-848c9d6bb5b2/download
File
MD5
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text/plain
ViralRespiratoryInfectionsVeryLow_2020.pdf.txt