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00925njm 22002777a 4500 dc Delgado-Sanz, Concepcion author Mazagatos, Clara author Oliva Dominguez, Jesus Angel author Gherasim, Alin Manuel author Larrauri, Amparo author 2020-02 We conducted a retrospective cohort study to assess the effect of influenza virus type and subtype on disease severity among hospitalized influenza patients in Spain. We analyzed the cases of 8,985 laboratory-confirmed case-patients hospitalized for severe influenza by using data from a national surveillance system for the period 2010-2017. Hospitalized patients with influenza A(H1N1)pdm09 virus were significantly younger, more frequently had class III obesity, and had a higher risk for pneumonia or acute respiratory distress syndrome than patients infected with influenza A(H3N2) or B (p<0.05). Hospitalized patients with influenza A(H1N1)pdm09 also had a higher risk for intensive care unit admission, death, or both than patients with influenza A(H3N2) or B, independent of other factors. Determining the patterns of influenza-associated severity and how they might differ by virus type and subtype can help guide planning and implementation of adequate control and preventive measures during influenza epidemics. Emerg Infect Dis. 2020 Feb;26(2):220-228. http://hdl.handle.net/20.500.12105/14929 31961295 10.3201/eid2602.181732 1080-6059 Emerging Infectious Diseases Spain Influenza A(H1N1)pdm09 Influenza A(H3N2) Influenza B Influenza hospitalizations Respiratory infections Severe influenza Surveillance Viral subtypes Viral types Viruses Influenza Illness Severity in Hospitalized Influenza Patients by Virus Type and Subtype, Spain, 2010-2017