2026-04-29T04:08:36Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/149262025-04-04T17:11:59Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608
Repisalud
author
Dafsari, Haidar S
author
Dos Santos Ghilardi, Maria Gabriela
author
Visser-Vandewalle, Veerle
author
Rizos, Alexandra
author
Ashkan, Keyoumars
author
Silverdale, Monty
author
Evans, Julian
author
Martinez, Raquel C R
author
Cury, Rubens G
author
Jost, Stefanie T
author
Barbe, Michael T
author
Fink, Gereon R
author
Antonini, Angelo
author
Chaudhuri, Kallol Ray
author
Martínez-Martín, Pablo
author
Fonoff, Erich Talamoni
author
Timmermann, Lars
author
EUROPAR Study Group
author
IPMDS Non Motor PD Study Group
funder
Thiemann Stiftung
funder
Felgenhauer Foundation
2022-09-02T08:32:09Z
2022-09-02T08:32:09Z
2020-12
Brain Stimul. 2020 Nov-Dec;13(6):1697-1705.
http://hdl.handle.net/20.500.12105/14926
33038595
10.1016/j.brs.2020.09.019
1876-4754
Brain Stimulation
Background: Subthalamic (STN) and pallidal (GPi) deep brain stimulation (DBS) improve quality of life, motor, and nonmotor symptoms (NMS) in advanced Parkinson’s disease (PD). However, few studies have compared their nonmotor effects. Objective: To compare nonmotor effects of STN-DBS and GPi-DBS. Methods: In this prospective, observational, multicenter study including 60 PD patients undergoing bilateral STN-DBS (n = 40) or GPi-DBS (n = 20), we examined PDQuestionnaire (PDQ), NMSScale (NMSS), Unified PD Rating Scale-activities of daily living, -motor impairment, -complications (UPDRS-II, –III, -IV), Hoehn&Yahr, Schwab&England Scale, and levodopa-equivalent daily dose (LEDD) preoperatively and at 6-month follow-up. Intra-group changes at follow-up were analyzed with Wilcoxon signed-rank or paired t-test, if parametric tests were applicable, and corrected for multiple comparisons. Inter-group differences were explored with Mann-Whitney-U/unpaired t-tests. Analyses were performed before and after propensity score matching which balanced out demographic and preoperative clinical characteristics. Strength of clinical changes was assessed with effect size. Results: In both groups, PDQ, UPDRS-II, -IV, Schwab&England Scale, and NMSS improved significantly at follow-up. STN-DBS was significantly better for LEDD reduction, GPi-DBS for UPDRS-IV. While NMSS total score outcomes were similar, explorative NMSS domain analyses revealed distinct profiles: Both targets improved sleep/fatigue and mood/cognition, but only STN-DBS the miscellaneous (pain/olfaction) and attention/memory and only GPi-DBS cardiovascular and sexual function domains. Conclusions: To our knowledge, this is the first study to report distinct patterns of beneficial nonmotor effects of STN-DBS and GPi-DBS in PD. This study highlights the importance of NMS assessments to tailor DBS target choices to patients’ individual motor and nonmotor profiles.
eng
Deep brain stimulation
Subthalamic nucleus
Globus Pallidus internus
Non-motor symptoms
Nonmotor symptoms
Quality of life
Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson's disease
research article
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