2026-04-29T04:09:38Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/149262025-04-04T17:11:59Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Dafsari, Haidar S author Dos Santos Ghilardi, Maria Gabriela author Visser-Vandewalle, Veerle author Rizos, Alexandra author Ashkan, Keyoumars author Silverdale, Monty author Evans, Julian author Martinez, Raquel C R author Cury, Rubens G author Jost, Stefanie T author Barbe, Michael T author Fink, Gereon R author Antonini, Angelo author Chaudhuri, Kallol Ray author Martínez-Martín, Pablo author Fonoff, Erich Talamoni author Timmermann, Lars author EUROPAR Study Group author IPMDS Non Motor PD Study Group author 2020-12 Background: Subthalamic (STN) and pallidal (GPi) deep brain stimulation (DBS) improve quality of life, motor, and nonmotor symptoms (NMS) in advanced Parkinson’s disease (PD). However, few studies have compared their nonmotor effects. Objective: To compare nonmotor effects of STN-DBS and GPi-DBS. Methods: In this prospective, observational, multicenter study including 60 PD patients undergoing bilateral STN-DBS (n = 40) or GPi-DBS (n = 20), we examined PDQuestionnaire (PDQ), NMSScale (NMSS), Unified PD Rating Scale-activities of daily living, -motor impairment, -complications (UPDRS-II, –III, -IV), Hoehn&Yahr, Schwab&England Scale, and levodopa-equivalent daily dose (LEDD) preoperatively and at 6-month follow-up. Intra-group changes at follow-up were analyzed with Wilcoxon signed-rank or paired t-test, if parametric tests were applicable, and corrected for multiple comparisons. Inter-group differences were explored with Mann-Whitney-U/unpaired t-tests. Analyses were performed before and after propensity score matching which balanced out demographic and preoperative clinical characteristics. Strength of clinical changes was assessed with effect size. Results: In both groups, PDQ, UPDRS-II, -IV, Schwab&England Scale, and NMSS improved significantly at follow-up. STN-DBS was significantly better for LEDD reduction, GPi-DBS for UPDRS-IV. While NMSS total score outcomes were similar, explorative NMSS domain analyses revealed distinct profiles: Both targets improved sleep/fatigue and mood/cognition, but only STN-DBS the miscellaneous (pain/olfaction) and attention/memory and only GPi-DBS cardiovascular and sexual function domains. Conclusions: To our knowledge, this is the first study to report distinct patterns of beneficial nonmotor effects of STN-DBS and GPi-DBS in PD. This study highlights the importance of NMS assessments to tailor DBS target choices to patients’ individual motor and nonmotor profiles. Brain Stimul. 2020 Nov-Dec;13(6):1697-1705. http://hdl.handle.net/20.500.12105/14926 33038595 10.1016/j.brs.2020.09.019 1876-4754 Brain Stimulation Deep brain stimulation Subthalamic nucleus Globus Pallidus internus Non-motor symptoms Nonmotor symptoms Quality of life Beneficial nonmotor effects of subthalamic and pallidal neurostimulation in Parkinson's disease