2026-07-21T15:46:28Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/148732024-11-29T18:46:17Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16988
Repisalud
author
Rodríguez-Mora, Sara
author
Corona, Magdalena
author
Torres, Montserrat
author
Casado-Fernández, Guiomar
author
García-Pérez, Javier
author
Ramos-Martín, Fernando
author
Vigon-Hernandez, Lorena
author
Manzanares, Mario
author
Mateos, Elena
author
Martín-Moro, Fernando
author
Zurdo-Castronuño, Alejandro
author
Murciano-Antón, María Aranzazu
author
Alcamí, José
author
Perez-Olmeda, Mayte
author
López-Jiménez, Javier
author
García-Gutiérrez, Valentín
author
Coiras, Mayte
author
Multidisciplinary Group of Study of COVID-19 (MGS-COVID)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
National Institutes of Health (Estados Unidos)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Hospital Universitario Ramón y Cajal
2022-08-05T14:06:41Z
2022-08-05T14:06:41Z
2022-05-16
J Clin Med. 2022 May 16;11(10):2803.
10.3390/jcm11102803
2077-0383
2077-0383
Journal of Cnical Medicine
35628927
http://hdl.handle.net/20.500.12105/14873
Individuals with oncohematological diseases (OHD) may develop an impaired immune response against vaccines due to the characteristics of the disease or to its treatment. Humoral response against SARS-CoV-2 has been described to be suboptimal in these patients, but the quality and efficiency of the cellular immune response has not been yet completely characterized. In this study, we analyzed the early humoral and cellular immune responses in individuals with different OHD after receiving one dose of an authorized vaccine against SARS-CoV-2. Humoral response, determined by antibodies titers and neutralizing capacity, was overall impaired in individuals with OHD, except for the cohort of chronic myeloid leukemia (CML), which showed higher levels of specific IgGs than healthy donors. Conversely, the specific direct cytotoxic cellular immunity response (DCC) against SARS-CoV-2, appeared to be enhanced, especially in individuals with CML and chronic lymphocytic leukemia (CLL). This increased cellular immune response, developed earlier than in healthy donors, showed a modest cytotoxic activity that was compensated by significantly increased numbers, likely due to the disease or its treatment. The analysis of the immune response through subsequent vaccine doses will help establish the real efficacy of COVID-19 vaccines in individuals with OHD.
eng
COVID-19 vaccine
Cytotoxic response
Early immune
Hematological malignancies
Humoral response
Early Cellular and Humoral Responses Developed in Oncohematological Patients after Vaccination with One Dose against COVID-19
research article
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EarlyCellularAndHumoral_2022.pdf.txt