2026-04-29T00:59:53Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/148632024-11-29T11:04:47Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16981

00925njm 22002777a 4500 dc Ojeda Sánchez, Carlos author García-Pérez, Javier author Gomez-Barroso, Diana author Domínguez-Castillo, Alejandro author Pardo Romaguera, Elena author Cañete, Adela author Ortega-García, Juan A author Ramis, Rebeca author 2022-04-25 Background: Blue spaces have been a key part of human evolution, providing resources and helping economies develop. To date, no studies have been carried out to explore how they may be linked to paediatric oncological diseases. Objectives: To explore the possible relationship of residential proximity to natural and urban blue spaces on childhood leukaemia. Methods: A population-based case–control study was conducted in four regions of Spain across the period 2000–2018. A total of 936 incident cases and 5616 controls were included, individually matched by sex, year of birth and place of residence. An exposure proxy with four distances (250 m, 500 m, 750 m, and 1 km) to blue spaces was built using the geographical coordinates of the participants’ home residences. Odds ratios (ORs) and 95% confidence intervals (95%CIs) for blue-space exposure were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic and environmental covariates. Results: A decrease in overall childhood leukaemia and ALL-subtype incidence was found as we came nearer to children’s places of residence, showing, for the study as a whole, a reduced incidence at 250 m (odds ratio (OR) = 0.77; 95%CI = 0.60–0.97), 500 m (OR = 0.78; 95%CI = 0.65–0.93), 750 m (OR = 0.80; 95%CI = 0.69–0.93), and 1000 m (OR = 0.84; 95%CI = 0.72–0.97). AML model results showed an increasing incidence at closest to subjects’ homes (OR at 250m = 1.06; 95%CI=0.63–1.71). Conclusions: Our results suggest a possible association between lower childhood leukaemia incidence and blue-space proximity. This study is a first approach to blue spaces’ possible effects on childhood leukaemia incidence; consequently, it is necessary to continue studying these spaces—while taking into account more individualised data and other possible environmental risk factors. Int J Environ Res Public Health. 2022 Apr 25;19(9):5232. http://hdl.handle.net/20.500.12105/14863 35564626 10.3390/ijerph19095232 1660-4601 International Journal of Environmental Research and Public Health Urban blue spaces Environmental factors Childhood cancer Childhood leukaemia Incidence Spatial epidemiology Exploring Blue Spaces' Effects on Childhood Leukaemia Incidence: A Population-Based Case-Control Study in Spain