2026-04-29T12:23:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/148172025-06-13T10:28:20Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617
Repisalud
author
Bartolomé, Fernando
author
Rosa, Luigi
author
Valenti, Piera
author
Lopera, Francisco
author
Hernández-Gallego, Jesús
author
Cantero, José Luis
author
Orive, Gorka
author
Carro, Eva
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Ministerio de Economía y Competitividad (España)
funder
Regional Government of Andalusia (España)
2022-08-03T07:55:35Z
2022-08-03T07:55:35Z
2022
Front Immunol. 2022 Apr 25;13:878201.
10.3389/fimmu.2022.878201
1664-3224
Frontiers in Immunology
35547737
http://hdl.handle.net/20.500.12105/14817
Coronavirus 2 (SARS-CoV2) (COVID-19) causes severe acute respiratory syndrome. Severe illness of COVID-19 largely occurs in older people and recent evidence indicates that demented patients have higher risk for COVID-19. Additionally, COVID-19 further enhances the vulnerability of older adults with cognitive damage. A balance between the immune and inflammatory response is necessary to control the infection. Thus, antimicrobial and anti-inflammatory drugs are hopeful therapeutic agents for the treatment of COVID-19. Accumulating evidence suggests that lactoferrin (Lf) is active against SARS-CoV-2, likely due to its potent antiviral and anti-inflammatory actions that ultimately improves immune system responses. Remarkably, salivary Lf levels are significantly reduced in different Alzheimer's disease (AD) stages, which may reflect AD-related immunological disturbances, leading to reduced defense mechanisms against viral pathogens and an increase of the COVID-19 susceptibility. Overall, there is an urgent necessity to protect AD patients against COVID-19, decreasing the risk of viral infections. In this context, we propose bovine Lf (bLf) as a promising preventive therapeutic tool to minimize COVID-19 risk in patients with dementia or AD.
eng
Alzheimer’s disease
COVID-19
SARS-CoV-2
Brain-immunity interactions
Dementia
Inflammation
Lactoferrin
Saliva
Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer's Disease Patients
research article
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URL
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File
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application/pdf
LactoferrinAsImmuneEnhancement_2020.pdf
URL
https://repisalud.isciii.es/bitstreams/0d48ca49-a8ee-448f-9116-593b7153b10e/download
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text/plain
LactoferrinAsImmuneEnhancement_2020.pdf.txt