2026-04-29T12:24:08Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/148172025-06-13T10:28:20Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16938col_20.500.12105_19617

00925njm 22002777a 4500 dc Bartolomé, Fernando author Rosa, Luigi author Valenti, Piera author Lopera, Francisco author Hernández-Gallego, Jesús author Cantero, José Luis author Orive, Gorka author Carro, Eva author 2022 Coronavirus 2 (SARS-CoV2) (COVID-19) causes severe acute respiratory syndrome. Severe illness of COVID-19 largely occurs in older people and recent evidence indicates that demented patients have higher risk for COVID-19. Additionally, COVID-19 further enhances the vulnerability of older adults with cognitive damage. A balance between the immune and inflammatory response is necessary to control the infection. Thus, antimicrobial and anti-inflammatory drugs are hopeful therapeutic agents for the treatment of COVID-19. Accumulating evidence suggests that lactoferrin (Lf) is active against SARS-CoV-2, likely due to its potent antiviral and anti-inflammatory actions that ultimately improves immune system responses. Remarkably, salivary Lf levels are significantly reduced in different Alzheimer's disease (AD) stages, which may reflect AD-related immunological disturbances, leading to reduced defense mechanisms against viral pathogens and an increase of the COVID-19 susceptibility. Overall, there is an urgent necessity to protect AD patients against COVID-19, decreasing the risk of viral infections. In this context, we propose bovine Lf (bLf) as a promising preventive therapeutic tool to minimize COVID-19 risk in patients with dementia or AD. Front Immunol. 2022 Apr 25;13:878201. 10.3389/fimmu.2022.878201 1664-3224 Frontiers in Immunology 35547737 http://hdl.handle.net/20.500.12105/14817 Alzheimer’s disease COVID-19 SARS-CoV-2 Brain-immunity interactions Dementia Inflammation Lactoferrin Saliva Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer's Disease Patients